CAJ | 학술논문

目的：研究类风湿因子（RF）、抗环瓜氨酸多肽（CCP）抗体和抗角蛋白抗体（AKA）联合检测在类风湿关节炎（RA）诊断中的价值。方法：分别应用免疫比浊法、ELISA法和间接免疫荧光染色法检测150例RA患者和75例非RA患者血清中的RF、抗CCP抗体和AKA水平，并分析三种抗体在RA诊断中的价值。结果：单一抗体检测中敏感性以RF最高（82.0%），特异性以AKA最高（93.33%），阳性预测值以AKA最高（94.05%），阴性预测值以RF最高（67.47%）；联合检测中敏感性以RF+抗CCP抗体最高（43.33%），特异性以RF+抗CCP+AKA最高（100%），阳性预测值以RF+抗CCP+AKA最高（100%），阴性预测值以RF+抗CCP抗体最高（44.81%）。结论：RF诊断RA的灵敏性最高，但特异性以RF+抗CCP+AKA最高，三者联合检测可以提高对RA的诊断价值。
목적：연구류풍습인자（RF）、항배과안산다태（CCP）항체화항각단백항체（AKA）연합검측재류풍습관절염（RA）진단중적개치。방법：분별응용면역비탁법、ELISA법화간접면역형광염색법검측150례RA환자화75례비RA환자혈청중적RF、항CCP항체화AKA수평，병분석삼충항체재RA진단중적개치。결과：단일항체검측중민감성이RF최고（82.0%），특이성이AKA최고（93.33%），양성예측치이AKA최고（94.05%），음성예측치이RF최고（67.47%）；연합검측중민감성이RF+항CCP항체최고（43.33%），특이성이RF+항CCP+AKA최고（100%），양성예측치이RF+항CCP+AKA최고（100%），음성예측치이RF+항CCP항체최고（44.81%）。결론：RF진단RA적령민성최고，단특이성이RF+항CCP+AKA최고，삼자연합검측가이제고대RA적진단개치。
Objective:To evaluate the significance of the combination of serum rheumatoid factor(RF),anticyclic citrullinated peptide antibody(anti CCP)and antikeratin antibody in the diagnostic value of rheumatoid arthritis(RA).Method:Serum from 150 RA patients and 75 non-RA patients were analyzed.RF,anti CCP and AKA were detected using immune turbidimetry、ELISA and indirect immunofluorescence respectively.The distributions of these antibodies were compared to determine the diagnostic values of combined detection of RF,anti CCP and AKA in RA patients.Result:The sensitivity of single antibody detection in RF was the highest(82.0%),specificity of AKA was the highest(93.33%),the positive predictive value of AKA was the highest(94.05%),and negative predictive value of RF was the highest(67.47%);the sensitivity of combined detection of anti CCP antibody to RF+in the highest(43.33%),specificity to RF+anti CCP+AKA was the highest(100%),the positive predictive value for RF+anti CCP+AKA was the highest (100%),and negative predictive value of RF+anti CCP antibody was highest(44.81%).Conclusion:RF diagnosis of RA sensitivity is highest,but specific to RF+anti CCP+AKA is the highest,the three combined detection can improve the diagnostic value of the RA.