CAJ | 학술논문

目的：探讨对感染性疾病补锌辅助治疗的疗效。方法收集1～12个月龄大的可能患有严重细菌感染的婴儿，随机分为两个组,补锌组87例和对照组80例，两组除标准的抗菌治疗外，补锌组每天接受口服硫酸锌2 mg/(kg·d),对照组接受同等剂量安慰剂，比较两组最终住院时间及严重症状缓解时间。结果两组间性别、月龄、疾病种类、疾病基础状态、高敏C反应蛋白水平、血锌水平比较无显著差异，P＞0.05；补锌组治疗失败7例（8.0%），对照组15例（18.7%），有统计学差异，P<0.05，补锌治疗降低了治疗失败的相对风险；补锌组住院时间10 d，对照组11 d，差异无统计学意义，P＞0.05；补锌组症状缓解时间3 d，对照组4 d，差异有统计学意义，P＜0.05。结论补锌治疗可降低抗感染失败的风险，可以加快严重感染症状的缓解。
목적：탐토대감염성질병보자보조치료적료효。방법수집1～12개월령대적가능환유엄중세균감염적영인，수궤분위량개조,보자조87례화대조조80례，량조제표준적항균치료외，보자조매천접수구복류산자2 mg/(kg·d),대조조접수동등제량안위제，비교량조최종주원시간급엄중증상완해시간。결과량조간성별、월령、질병충류、질병기출상태、고민C반응단백수평、혈자수평비교무현저차이，P＞0.05；보자조치료실패7례（8.0%），대조조15례（18.7%），유통계학차이，P<0.05，보자치료강저료치료실패적상대풍험；보자조주원시간10 d，대조조11 d，차이무통계학의의，P＞0.05；보자조증상완해시간3 d，대조조4 d，차이유통계학의의，P＜0.05。결론보자치료가강저항감염실패적풍험，가이가쾌엄중감염증상적완해。
Objective To explore the efifcacy of the auxiliary treatment of zinc supplementation to infectious disease. Methods We enrolled infants aged 1-12 months with probable serious bacterial infection,from July 2011 to May 2013.They were randomly divided into two groups, to receive either zinc sulfate 2 mg/(kg?d) or placebo in addition to the standard antibiotic treatment. Outcome is length of hospital stay and duration of severe symptoms. Results 87 infants were randomly assigned to receive zinc and 80 to placebo. There is no signiifcant difference between sex, age, disease types, basic status, high-sensitivity c-reactive protein levels and blood zinc levels , P>0.05;There is lower percent of treatment failures occurred in the zinc group [7(8.0%)] than in the placebo group [15(18.7%)], P<0.05.zinc reduce the risk of treatment failure;Zinc group were in hospital for 10 days, but the placebo group for 11 days. There are no statistical signiifcance, P>0.05;Zinc group of duration of severe symptoms was 3 days, and the placebo group was 4 days. There was statistically signiifcant, P<0.05. Conclusion Zinc could be given as adjunct treatment to reduce the risk of treatment failure and may speed up attenuation of severe symptoms in infants with probable serious bacterial infection.