CAJ | 학술논문

目的：了解常州地区女性人乳头瘤病毒（HPV）感染基因亚型分布及年龄特点。方法利用基因芯片技术，对来我院就诊的4600例女性进行生殖道HPV基因亚型分析。结果 HPV总感染率为22.52%，其中高危亚型感染占总感染的78.34%；多重感染占总感染的32.72%，以双重感染多见。常见的5种高危亚型为HPV16，52，58，51，39型，常见的2种低危亚型为HPV54，6型。51岁~60岁感染率较高。结论常州地区女性HPV感染率较高，且多重感染率高，年龄以50岁~60岁高发。
목적：료해상주지구녀성인유두류병독（HPV）감염기인아형분포급년령특점。방법이용기인심편기술，대래아원취진적4600례녀성진행생식도HPV기인아형분석。결과 HPV총감염솔위22.52%，기중고위아형감염점총감염적78.34%；다중감염점총감염적32.72%，이쌍중감염다견。상견적5충고위아형위HPV16，52，58，51，39형，상견적2충저위아형위HPV54，6형。51세~60세감염솔교고。결론상주지구녀성HPV감염솔교고，차다중감염솔고，년령이50세~60세고발。
Objective To investigate the distribution and age characteristics of the genetic subtypes of human papillomavirus (HPV) infection in women in Changzhou. Methods A study was performed involving a sample of 4600 women from our hospital. Gene chips were used to detect of HPV-DNA in cervical specimens. Results The positive rate of HPV infection was 22.56%, among which high-risk genotype rate was 78.34%. Multiple genotype infection rate was 32.72%, among which double was the most common type. The five most common high-risk subtypes were HPV16 , 52, 58, 51, 39 and two most common low-risk subtypes were HPV54, 6. There was relatively high infection rate among 51~60 years old women. Conclusion The infection rate of HPV is high in Changzhou. Multiple infection accounts for relatively large ratio. Age 50-60 is high-risk stage of HPV infection for women.