福建医科大学学报
福建醫科大學學報
복건의과대학학보
JOURNAL OF FUJIAN MEDICAL UNIVERSITY
2013年
4期
232-235
,共4页
韩英%刘楠%黄慧玲%徐春平%晏泽辉
韓英%劉楠%黃慧玲%徐春平%晏澤輝
한영%류남%황혜령%서춘평%안택휘
帕金森病%抑郁%认知障碍%运动障碍%精神病状态评定量表
帕金森病%抑鬱%認知障礙%運動障礙%精神病狀態評定量錶
파금삼병%억욱%인지장애%운동장애%정신병상태평정량표
Parkinson disease%depression%cognition disorders%movement disorders%psychiatric status rating scales
目的:探讨帕金森病(PD)患者伴发抑郁与认知功能障碍及运动障碍之间的影响。方法采用汉密尔顿抑郁量表(HAMD)对46例PD患者进行评分,HAMD≥17分为抑郁组,HAMD<17分为非抑郁组;应用简易精神状态检查(MMSE)、画钟测验(CDT )、词语流畅性测验(VFT )、统一PD评价量表(UPDRS)运动分量表评定两组患者的认知功能和运动功能,计算震颤症状得分与运动迟缓症状得分之比,>0.5者为震颤型组,≤0.5者为强直-少动型组,分析两组的HAMD评分情况,HAMD评分与比值之间的Pearson相关系数。结果抑郁组和非抑郁组之间认知功能评分(MMSE、CDT、VFT 评分)和运动功能评分(运动迟缓评分)差别具有统计学意义(分别为 P<0.01,P<0.05,P<0.01,P<0.01),而震颤评分无统计学意义(P>0.05);强直少动型组 HAMD评分明显高于震颤型组( P<0.01),同时 HAMD 评分与震颤评分/运动迟缓评分之比之间存在负相关(r=-0.523, P<0.01)。结论PD患者抑郁情绪会加重认知功能障碍及运动功能障碍程度。
目的:探討帕金森病(PD)患者伴髮抑鬱與認知功能障礙及運動障礙之間的影響。方法採用漢密爾頓抑鬱量錶(HAMD)對46例PD患者進行評分,HAMD≥17分為抑鬱組,HAMD<17分為非抑鬱組;應用簡易精神狀態檢查(MMSE)、畫鐘測驗(CDT )、詞語流暢性測驗(VFT )、統一PD評價量錶(UPDRS)運動分量錶評定兩組患者的認知功能和運動功能,計算震顫癥狀得分與運動遲緩癥狀得分之比,>0.5者為震顫型組,≤0.5者為彊直-少動型組,分析兩組的HAMD評分情況,HAMD評分與比值之間的Pearson相關繫數。結果抑鬱組和非抑鬱組之間認知功能評分(MMSE、CDT、VFT 評分)和運動功能評分(運動遲緩評分)差彆具有統計學意義(分彆為 P<0.01,P<0.05,P<0.01,P<0.01),而震顫評分無統計學意義(P>0.05);彊直少動型組 HAMD評分明顯高于震顫型組( P<0.01),同時 HAMD 評分與震顫評分/運動遲緩評分之比之間存在負相關(r=-0.523, P<0.01)。結論PD患者抑鬱情緒會加重認知功能障礙及運動功能障礙程度。
목적:탐토파금삼병(PD)환자반발억욱여인지공능장애급운동장애지간적영향。방법채용한밀이돈억욱량표(HAMD)대46례PD환자진행평분,HAMD≥17분위억욱조,HAMD<17분위비억욱조;응용간역정신상태검사(MMSE)、화종측험(CDT )、사어류창성측험(VFT )、통일PD평개량표(UPDRS)운동분량표평정량조환자적인지공능화운동공능,계산진전증상득분여운동지완증상득분지비,>0.5자위진전형조,≤0.5자위강직-소동형조,분석량조적HAMD평분정황,HAMD평분여비치지간적Pearson상관계수。결과억욱조화비억욱조지간인지공능평분(MMSE、CDT、VFT 평분)화운동공능평분(운동지완평분)차별구유통계학의의(분별위 P<0.01,P<0.05,P<0.01,P<0.01),이진전평분무통계학의의(P>0.05);강직소동형조 HAMD평분명현고우진전형조( P<0.01),동시 HAMD 평분여진전평분/운동지완평분지비지간존재부상관(r=-0.523, P<0.01)。결론PD환자억욱정서회가중인지공능장애급운동공능장애정도。
Objective To investigate effect of depression on cognitive and movement dysfunction in patients with Parkinson's disease (PD) . Methods 46 patients with PD patients were enrolled and eval-uated by Hamilton depression rating Scale (HAMD) . Patients with scores ≥17 were defined as depres-sion ,and scores <17 as non-depression . Cognitive function and motor function were assessed by Mini-mental state examination (MMSE) ,Clock drawing test (CDT ) ,Verbal fluency test (VFT ) and Unified parkinson’s disease rating scale(UPDRS) subscales . The ratio of the tremor symptoms score/bradykine-sia symptoms score was calculated ,patients with scores >0 .5 were defined as tremor type group ,and those with scores ≤0 .5 as tonic-less acting group . The correlation of HAMD score and the ratio of the tremor symptoms score/bradykinesia symptoms score were analyzed by the Pearson correlation between depression and non-depression groups . Results In PD patients with or without depression ,there was statistically significant differences in cognitive function score (MMSE ,CDT ,VFT score) and motor func-tion score (bradykinesia score) P<0 .05 or P<0 .01 respectively ;however ,there was no significant differ-ence in tremor score . The HAMD score in Tonic less-action group was significantly higher than that in the tremor-type group (P<0 .01) . There was a negative correlation between the HAMD score and the ratio of tremor score /bradykinesia score(r= -0 .523 ,P<0 .01) . Conclusions PD patients with depres-sion have worse cognitive dysfunction and movement dysfunction .