CAJ | 학술논문

目的：评价钩吻素子产生吗啡样药物依赖性的潜力。方法采用离体豚鼠回肠药物依赖模型、小鼠药物依赖催促戒断模型和自然戒断模型，分析钩吻素子诱导吗啡样身体依赖性的潜力；进而通过小鼠条件性位置偏爱实验评价钩吻素子诱导吗啡样精神依赖性的潜力。结果钩吻素子孵育的离体豚鼠回肠未出现吗啡样纳洛酮催促的戒断反应；小鼠连续给予钩吻素子，未出现吗啡样纳洛酮催促的跳跃、体质量下降和自然戒断的体质量下降等戒断反应；也未见吗啡样条件性位置偏爱效应。结论钩吻素子可能无吗啡样药物身体依赖性和精神依赖性的潜力。
목적：평개구문소자산생마배양약물의뢰성적잠력。방법채용리체돈서회장약물의뢰모형、소서약물의뢰최촉계단모형화자연계단모형，분석구문소자유도마배양신체의뢰성적잠력；진이통과소서조건성위치편애실험평개구문소자유도마배양정신의뢰성적잠력。결과구문소자부육적리체돈서회장미출현마배양납락동최촉적계단반응；소서련속급여구문소자，미출현마배양납락동최촉적도약、체질량하강화자연계단적체질량하강등계단반응；야미견마배양조건성위치편애효응。결론구문소자가능무마배양약물신체의뢰성화정신의뢰성적잠력。
Objective To evaluate whether Koumine produces morphine-like drug dependence . Methods Morphine-like physical dependence potential of Koumine was evaluated by the drug dependence model of isolated guinea-pig ileum ,mouse drug dependence precipitated withdrawal model and natural withdrawal model . Morphine-like psychological dependence potential of Koumine was assessed by the conditioned place preference testing . Results Isolated guinea-pig ileum incubated with Koumine showed no signs of naloxone precipitated morphine-like withdrawal symptoms . Mice repeatedly administered with Koumine showed neither morphine-like naloxone precipitated withdrawal symptoms such as jumping , body weight loss and natural withdrawal body weight loss ,nor morphine-like conditioned place preference . Conclusion Koumine might not induce morphine-like physical and psychological dependence .