CAJ | 학술논문

为研究不同浓度的氮酮对丹皮酚巴布剂体外透皮吸收的影响，采用改良Franz扩散池法，液相色谱外标法检测丹皮酚的透过率；在丹皮酚巴布剂基质的制作过程中，分别加入2％、3％、4％的氮酮，检测不同浓度的氮酮对丹皮酚体外透皮吸收的影响；与空白组对照，2％、3％、4％的氮酮对丹皮酚的体外透皮吸收均有显著影响（P ＜0．01，P ＜0．01，P ＜0．01），对丹皮酚透皮速率提高大小顺序为3％的氮酮＞2％的氮酮＞4％的氮酮；得出氮酮可作为丹皮酚巴布剂的透皮促进剂。
위연구불동농도적담동대단피분파포제체외투피흡수적영향，채용개량Franz확산지법，액상색보외표법검측단피분적투과솔；재단피분파포제기질적제작과정중，분별가입2％、3％、4％적담동，검측불동농도적담동대단피분체외투피흡수적영향；여공백조대조，2％、3％、4％적담동대단피분적체외투피흡수균유현저영향（P ＜0．01，P ＜0．01，P ＜0．01），대단피분투피속솔제고대소순서위3％적담동＞2％적담동＞4％적담동；득출담동가작위단피분파포제적투피촉진제。
Objective:to study the effects of different concentrations of azone on paeonol poultice per-cutaneous absorption in vitro of mice .Methods :using the modified Franz diffusion pool and HPLC exter-nal standard method to test the transmittance of paeonol .2% ,3% ,4% azone were added in the produc-tion process of paeonol poultice matrix respectively ,for testing the effects of different concentrations of azone on paeonol poultice percutaneous absorption in vitro of mice .Results :compared with normal control group ,2% ,3% ,4% azone increased paeonol poultice percutaneous absorption in vitro of mice significant-ly (P < 0 .01 ,P < 0 .01 ,P <0 .01) .Conclusion:Azone could be used as a accelerant of paeonol poultice percutaneous absorption .