CAJ | 학술논문

目的：观察瑞舒伐他汀对病态窦房结综合征（sick sinus syndrome ，SSS ）合并阵发性心房颤动（atrial fibrillation ，PAF）双腔起搏器（dual chamber pacemaker ，DDD）术后心房高频事件（atrial high-frequency events ， AHREs）的影响。方法选择具有DDD植入术指征的SSS合并PAF成功行DDD植入术患者65例，随机分为观察组（34例）、对照组（31例），两组术后均服用美托洛尔缓释片（23．75mg 早1次）、观察组加用瑞舒伐他汀（10mg ，晚1次）。随访观察12个月，比较观察组与对照组患者服药1a后心房、心室起搏特点、C反应蛋白（C-reactive protein ，CRP）差异性及心房高频事件（包括发作次数、发作持续时间）发生情况。结果治疗12个月后，观察组与对照组心房起搏、心室起搏比例无显著差异，而观察组CRP值较对照组显著降低，且差异具有统计学意义。比较两组起搏器程控时记录到的心房高频事件，观察组心房高频事件较对照组明显减少﹙ P＜0．05﹚，差异具有统计学意义。结论瑞舒伐他汀可以抑制病窦综合征伴阵发房颤患者双腔起搏术后心房重构、炎症反应，进而减少心房高频事件的发生。
목적：관찰서서벌타정대병태두방결종합정（sick sinus syndrome ，SSS ）합병진발성심방전동（atrial fibrillation ，PAF）쌍강기박기（dual chamber pacemaker ，DDD）술후심방고빈사건（atrial high-frequency events ， AHREs）적영향。방법선택구유DDD식입술지정적SSS합병PAF성공행DDD식입술환자65례，수궤분위관찰조（34례）、대조조（31례），량조술후균복용미탁락이완석편（23．75mg 조1차）、관찰조가용서서벌타정（10mg ，만1차）。수방관찰12개월，비교관찰조여대조조환자복약1a후심방、심실기박특점、C반응단백（C-reactive protein ，CRP）차이성급심방고빈사건（포괄발작차수、발작지속시간）발생정황。결과치료12개월후，관찰조여대조조심방기박、심실기박비례무현저차이，이관찰조CRP치교대조조현저강저，차차이구유통계학의의。비교량조기박기정공시기록도적심방고빈사건，관찰조심방고빈사건교대조조명현감소﹙ P＜0．05﹚，차이구유통계학의의。결론서서벌타정가이억제병두종합정반진발방전환자쌍강기박술후심방중구、염증반응，진이감소심방고빈사건적발생。
Objective To evaluate the effect of rosuvastatin on reducing paroxysmal atrial fibrillation after du-al-chamber-pacemaker implantation in patients who sicked sinus syndrome (SSS)and paroxysmal atrial fibrillation . Methods Sixty-five patients with SSS who was suffering from PAF following dual-chamber-pacemaker implanta-tion were randomly divided into the treatment group and the control group .On the basis of the treatment of original diseases ,the control group were given metoprolol ,while the treatment group were administrated with rosuvasta-tin ,10mg served everyday ,as well as metoprolol .After twelve months follow-up and observation ,CRP ,AP% , VP% ,the PAF times and AF duration(AHREs)were observed .Results CRP ,PAF times and AF persistence time (AHREs)recorded by the pacemaker .The effective power of AF treatment in the treatment group were lower than those in the control group ( P<0 .05 ) ,and in the treatment goup they were decreased significantly .Conclusion Rosuvastation can effectively inhibit the occurrence of PAF after dual-chamber-pacemaker implantation in patients with SSS who were suffered with PAF by inhibiting atrial remodeling and Inflammatory reaction .