CAJ | 학술논문

目的：探讨齐拉西酮与喹硫平对精神分裂症患者的临床疗效和认知功能的影响。方法将60例精神分裂症患者随机分为两组，每组30例，分别口服齐拉西酮和喹硫平治疗，观察12周。采用阳性与阴性症状量表评定临床疗效，副反应量表评定不良反应，公认认知功能成套测验评定认知功能。结果治疗后两组阳性与阴性症状量表评分较治疗前显著降低（P＜0．01），公认认知功能成套测验评分均较治疗前显著升高（P＜0．01），同期两组间比较差异均无显著性（P＞0．05）；两组不良反应发生率比较差异无显著性（P＞0．05）。结论齐拉西酮与喹硫平治疗精神分裂症疗效显著，安全性高，均能有效改善患者的认知功能。
목적：탐토제랍서동여규류평대정신분렬증환자적림상료효화인지공능적영향。방법장60례정신분렬증환자수궤분위량조，매조30례，분별구복제랍서동화규류평치료，관찰12주。채용양성여음성증상량표평정림상료효，부반응량표평정불량반응，공인인지공능성투측험평정인지공능。결과치료후량조양성여음성증상량표평분교치료전현저강저（P＜0．01），공인인지공능성투측험평분균교치료전현저승고（P＜0．01），동기량조간비교차이균무현저성（P＞0．05）；량조불량반응발생솔비교차이무현저성（P＞0．05）。결론제랍서동여규류평치료정신분렬증료효현저，안전성고，균능유효개선환자적인지공능。
Objective To explore the influence of ziprasidone and quetiapine on efficacy and cognitive function of schizophrenic .Methods Sixty schizophrenics were randomly assessed to two groups of 30 ones each and treated with ziprasidone or quetiapine for 12 weeks .Efficacies were assessed with the Positive and Negative Symptoms Scale (PANSS ) ,adverse reactions with the Treatment Emergent Symptom Scale (TESS) and cognitive functions with the Matrics Consensus Cognitive Battery (MCCB) .Results The PANSS scores of both groups lowered more significantly (P<0 .01) and the MCCB heightened (P<0 .01) compared with pre-treatment ,there were no significant group differences (P>0 .05);there were no signifi-cant group differences in incidences of adverse reactions (P>0 .05) .Conclusion Both ziprasidone and que-tiapine had an evident effect and higher safety in schizophrenia and could effectively improve patients ’ cog-nitive function .