CAJ | 학술논문

目的：研究玻璃体切除联合全氟丙烷（C3 F8）填充术后形成白内障的兔房水碱性成纤维细胞生长因子（bFGF）含量变化与白内障形成之间的关系。方法18只成年纯系新西兰白兔（雌雄不限）的36只眼，随机平均分为3组：正常组，不做手术；对照组，行单纯玻璃体切除术及眼前房灌注液（BSS ）填充；实验组，行玻璃体切除联合C3 F8填充术。术后第1，3，8，35及45天观察各组白内障的形成情况，并抽取房水用ELISA法检测房水中bFGF的含量。结果正常组与对照组均未出现晶体混浊，实验组均出现晶体混浊。术后不同时期，实验组与对照组的bFGF含量均明显高于正常组。术后第1，3，8天，实验组的bFGF含量明显高于对照组，有显著性差异（P＜0．05）。结论 C3 F8填充引起房水中bFGF的升高与引发一过性白内障的形成有关。
목적：연구파리체절제연합전불병완（C3 F8）전충술후형성백내장적토방수감성성섬유세포생장인자（bFGF）함량변화여백내장형성지간적관계。방법18지성년순계신서란백토（자웅불한）적36지안，수궤평균분위3조：정상조，불주수술；대조조，행단순파리체절제술급안전방관주액（BSS ）전충；실험조，행파리체절제연합C3 F8전충술。술후제1，3，8，35급45천관찰각조백내장적형성정황，병추취방수용ELISA법검측방수중bFGF적함량。결과정상조여대조조균미출현정체혼탁，실험조균출현정체혼탁。술후불동시기，실험조여대조조적bFGF함량균명현고우정상조。술후제1，3，8천，실험조적bFGF함량명현고우대조조，유현저성차이（P＜0．05）。결론 C3 F8전충인기방수중bFGF적승고여인발일과성백내장적형성유관。
Objective To investigate the possible correlationship between the content of bFGF in the aqueous humor and the development of PCO(posterior capsular opacity )following the joint operation of vitrectomy and C 3 F8 tamponade .Methods 18 adult and pure-breed New Zealand white rabbits were selected ,and all their 36 eyes as subjects of the experiment were taken .They were assigned into three groups randomly ,i .e .12 eyes per group . Blank control group would receive none operation .Control group which would undergo the vitrectomy .Experimen-tal group which would accept the joint operation of vitrectomy and C 3 F8 tamponade .Afterwards ,the development of PCO was observed and the bFGF content was measured in subject's aqueous humor on the next 1 ,3 ,8 ,35 ,45 days respectively .Results All subjects in blank control group and control group hadn't shown PCO during the experi-ment .All subjects in experimental group had shown PCO .The bFGF in control group and experimental group were significantly higher than blank control group .Experimental group was also higer than Control group throughtout the experimental period .Conclusion C3 F8 tamponade will raise the content of bFGF in the aqueous humor which may potentially contribute to the development of PCO .