CAJ | 학술논문

目的：香草醛( vanillin)是一种重要的天然产物，具有镇静、催眠、止痛、抗癫痫等生物活性，希夫碱是具有抗炎、杀菌作用的亚胺类化合物。此项研究的目的就是要找到兼有香草醛的活性和希夫碱功效的化合物，筛选具有镇静、抗癫痫、抗癌的药物。方法：以葡萄糖、香草醛为原料经过乙酰化，溴代等步骤合成了中间体四乙酰葡萄糖香草醛苷，然后与对甲苯胺反应。结果：合成了目标化合物V。结论：对目标化合物V用元素分析( PE 2400)、红外光谱(IR)、核磁共振氢谱(1 HNMR)、进行结构表征，分析证实所合成的化合物与预期结构一致。
목적：향초철( vanillin)시일충중요적천연산물，구유진정、최면、지통、항전간등생물활성，희부감시구유항염、살균작용적아알류화합물。차항연구적목적취시요조도겸유향초철적활성화희부감공효적화합물，사선구유진정、항전간、항암적약물。방법：이포도당、향초철위원료경과을선화，추대등보취합성료중간체사을선포도당향초철감，연후여대갑분알반응。결과：합성료목표화합물V。결론：대목표화합물V용원소분석( PE 2400)、홍외광보(IR)、핵자공진경보(1 HNMR)、진행결구표정，분석증실소합성적화합물여예기결구일치。
Objective:To search for compounds of Schiff base which have both vanillin's bioactivity and Schiff bases. They could be used as sedative,antiepileptic and anticancer drugs. Methods:Tetra-o-acetyl-α-D-vanillin-glucoside was synthesized by acetylation and bromination and other steps with glucose and vanillin. It was reacted with p-aminotoluene. Result: Compound V was obtained and the structure of it was identified by PE 2400、IR、1 HNMR. Conclusion:Schiff base can be synthesized by structure reformation and modification on vanillin based on Combination Principle of Medicine[1] .