CAJ | 학술논문

目的：探讨药物夫西地酸钠对血清胆汁酸（TBA）检验结果的影响。方法采用酶循环法测定血清中的TBA含量。以蒸馏水为对照，分别测定血清、夫西地酸钠和蒸馏水混合溶液及其不同浓度的稀释液、夫西地酸钠和血清混合溶液及其不同浓度的稀释液中的TBA含量，每个样品重复3次。结果血清TBA浓度为4.4μmol/L；夫西地酸钠蒸馏水混合溶液及其2、4、8、16倍稀释液的TBA平均浓度分别为226.53、130.42、77.12、40.78、21.47μmol/L；夫西地酸钠血清溶液及其2、4、8、16倍稀释液的TBA平均浓度分别为233.17、138.82、85.47、47.91、25.58μmol/L。结论实验证明夫西地酸钠可严重影响血清中TBA含量的测定，使检验结果显著升高。因此对需要检测肝功能的患者，建议检测前禁止服用夫西地酸钠。
목적：탐토약물부서지산납대혈청담즙산（TBA）검험결과적영향。방법채용매순배법측정혈청중적TBA함량。이증류수위대조，분별측정혈청、부서지산납화증류수혼합용액급기불동농도적희석액、부서지산납화혈청혼합용액급기불동농도적희석액중적TBA함량，매개양품중복3차。결과혈청TBA농도위4.4μmol/L；부서지산납증류수혼합용액급기2、4、8、16배희석액적TBA평균농도분별위226.53、130.42、77.12、40.78、21.47μmol/L；부서지산납혈청용액급기2、4、8、16배희석액적TBA평균농도분별위233.17、138.82、85.47、47.91、25.58μmol/L。결론실험증명부서지산납가엄중영향혈청중TBA함량적측정，사검험결과현저승고。인차대수요검측간공능적환자，건의검측전금지복용부서지산납。
Objective To investigate the effects of Sodium Fusidate on detections of serium total blile acid(TBA). Methods Serium TBA was detected by using the circulating enzymatic method. Distilled water was treated as a control, the amount of TBA was analyzed in different solutions as follows:in serium;in the mixture of Sodium Fusidate and distilled water and in its different concentrations respectively; and in the mixture of Sodium Fusidate and serium and in its different concentrations respectively. Each solution was analyzed triplicatedly. Results The average Serium TBA was 4.4 μmol/L. However, the average amount of TBA in the mixture of Sodium Fusidate and distilled water and in its dilutions of 2, 4, 8, 16 times were 226.53, 130.42, 77.12, 40.78, 21.47 μmol/L respectively. Correspondendly, the average results of Sodium Fusidate serium mixture and its 2, 4, 8, 16 times dilutions were 233.17, 138.82, 85.47, 47.91, 25.58 μmol/L respectively. Conclusion The assays desmontrate that Sodium Fusidate could severely affect the detection of serium TBA and give rise to signiifcant increases. Therefore, it is suggested that those patients who need to know their liver functions should stop taking Sodium Fusidate before doing the tests.