CAJ | 학술논문

水通道蛋白普遍存在于人体组织器官的细胞膜上，跨过脂质双分子层转运水及其它小分子物质，调节人体内的水平衡代谢。近年来研究发现水通道蛋白是羊水平衡的重要通道，参与母胎的液体交换。水通道蛋白9作为水通道蛋白家族中重要成员之一，目前被认为表达于人类的胎膜和胎盘，可能是羊水膜内调节中的一种重要的水通道。对水通道蛋白9在人胎盘胎膜的分布以及水通道蛋白9与羊水量异常相关性的深入研究，有助于探索羊水量异常的发生机制，从而为治疗羊水量异常提供新的思路和方向。为进一步明确羊水量异常的发病机制以指导临床的诊治，该文就国内外水通道蛋白9及其与羊水量异常关系的研究进展进行了综述。
수통도단백보편존재우인체조직기관적세포막상，과과지질쌍분자층전운수급기타소분자물질，조절인체내적수평형대사。근년래연구발현수통도단백시양수평형적중요통도，삼여모태적액체교환。수통도단백9작위수통도단백가족중중요성원지일，목전피인위표체우인류적태막화태반，가능시양수막내조절중적일충중요적수통도。대수통도단백9재인태반태막적분포이급수통도단백9여양수량이상상관성적심입연구，유조우탐색양수량이상적발생궤제，종이위치료양수량이상제공신적사로화방향。위진일보명학양수량이상적발병궤제이지도림상적진치，해문취국내외수통도단백9급기여양수량이상관계적연구진전진행료종술。
Aquaporin ( AQP ) , which exists widely in cell membrane of human tissues and organs , passes through lipidic bilayer ( phospholipid bilayer ) to transport water and other small molecules and regulates water metabolic balance in body .Recent studies have found that AQP is an important passage for amnion fluid balance and maternal-fetal fluid exchange .As one of the important members of the AQPs family, AQP9 is now believed to be expressed in human fetal membrane and placenta , and it may be an important water passage for amniotic fluid intramembrane regulation .Deep investigationes on distribution of AQP 9 in fetal membranes and placenta and its relationship with amniotic fluid volume abnormality is contributive to explore mechanisms of amniotic fluid volume abnormality , so as to provide a new idea and direction for the treatment .In order to further clarify the pathogenesis of abnormal amniotic fluid volume and to guide the clinical diagnosis and treatment , the article reviewed recent advance both at home and abroad in AQP 9 and its relationship with amniotic fluid volume abnormality .