CAJ | 학술논문

目的：研究川崎病患儿外周血11β-羟基类固醇脱氢酶（11β-HSD）的变化，为应用糖皮质激素治疗川崎病提供理论依据。方法检测并比较病例组、健康对照组患儿及病例组患儿丙种球蛋白（2g/kg）治疗前、治疗后第3天外周血中11β-HSD1和11β-HSD2的水平。结果11β-HSD1水平免疫球蛋白治疗前病例组（8．21±2．83ng/mL）高于对照组（6．61±0．65ng/mL），两组间比较有显著性差异（t＝3．29，P＜0．05）；治疗后病例（5．63±3．36ng/mL）组低于对照组（6．61±0．65ng/mL），两组间比较无显著性差异（P＞0．05）。11β-HSD2水平免疫球蛋白治疗前病例组（2．30±1．46ng/mL）低于对照组（3．18±1．34ng/mL），两组间比较有显著性差异（t＝-2．62，P＜0．05）；治疗后病例组（2．98±1．43ng/mL）低于对照组（3．18±1．34ng/mL），两组间比较无显著性差异（P＞0．05）。结论川崎病发病初期，体内存在的炎症因子影响11β-HSD的表达。早期应用糖皮质激素可能会发挥更有效的抗炎作用。
목적：연구천기병환인외주혈11β-간기류고순탈경매（11β-HSD）적변화，위응용당피질격소치료천기병제공이론의거。방법검측병비교병례조、건강대조조환인급병례조환인병충구단백（2g/kg）치료전、치료후제3천외주혈중11β-HSD1화11β-HSD2적수평。결과11β-HSD1수평면역구단백치료전병례조（8．21±2．83ng/mL）고우대조조（6．61±0．65ng/mL），량조간비교유현저성차이（t＝3．29，P＜0．05）；치료후병례（5．63±3．36ng/mL）조저우대조조（6．61±0．65ng/mL），량조간비교무현저성차이（P＞0．05）。11β-HSD2수평면역구단백치료전병례조（2．30±1．46ng/mL）저우대조조（3．18±1．34ng/mL），량조간비교유현저성차이（t＝-2．62，P＜0．05）；치료후병례조（2．98±1．43ng/mL）저우대조조（3．18±1．34ng/mL），량조간비교무현저성차이（P＞0．05）。결론천기병발병초기，체내존재적염증인자영향11β-HSD적표체。조기응용당피질격소가능회발휘경유효적항염작용。
Objective To investigate the changes of 11-beta hydroxysteroid dehydrogenase ( 11β-HSD ) levels in peripheral blood of children with Kawasaki disease (KD), so as to provide theoretical basis for application of glucocorticoid (GC) in the treatment of KD. Methods The levels of 11β-HSD1 and 11β-HSD2 in peripheral blood were respectively detected in case group , healthy control group and in case group before and 3 days after the treatment with immunoglobulin (2g/kg).Results Before the treatment with immunoglobulin the level of 11β-HSD1 of case group (8.21 ±2.83ng/mL) was higher than that of the control group (6.61 ±0.65ng/mL).Comparison between two groups showed significant difference (t=3.29, P<0.05).But the level of 11β-HSD1 of case group after treatment (5.63 ±3.36ng/mL) was lower than that of the control group (6.61 ±0.65ng/mL), and there was no significant difference between them (P>0.05).The level of 11β-HSD2 of case group (2.30 ±1.46ng/mL) was lower than that of the control group (3.18 ±1.34ng/mL) prior to treatment, and the difference was significant (t=-2.62,P<0.05).After treatment the level of 11β-HSD2 of case group (2.98 ±1.43ng/mL) was lower than that of the control group (3.18 ±1.34ng/mL), and there was no significant difference between them (P>0.05).Conclusion In the early stage of KD , inflammatory factor can influence the expression of 11β-HSD.Early use of corticosteroids may exert more effective anti-inflammatory effect .