CAJ | 학술논문

目的探讨并比较自体血清滴眼液和小牛血去蛋白提取物眼用凝胶在翼状胬肉切除术后角膜修复中的治疗效果.方法对2012年2月至2013年2月在武汉市中心医院眼科就诊的60例翼状胬肉患者行翼状胬肉切除联合角膜缘于细胞移植术,术后分别应用自体血清滴眼液或小牛血去蛋白提取物眼用凝胶点眼.术后随访3个月,观察两种滴眼液在翼状胬肉术后角膜修复中的治疗效果.结果自体血清滴眼液组术后3d时自觉异物感、卡痛等症状明显减轻,4d时仅有轻度异物感;小牛血去蛋白提取物眼用凝胶组术后4d时畏光、流泪开始减轻,6d时异物感明显消失.角膜上皮平均修复时间自体血清组(2.55±1.31)d,与小牛血去蛋白提取物眼用凝胶组(3.55±1.23)d相比,差异有统计学意义(P＜0.05).术后视力恢复两组对比差异无统计学意义(P＞0.05).手术治疗后3个月,所有患者无感染、排斥及其他并发症.结论自体血清滴眼液和小牛血去蛋白提取物眼用凝胶均能有效地治疗翼状胬肉切除术后的角膜上皮缺损,两者疗效无明显差异.自体血清滴眼液组患者术后相对恢复较快,自觉异物感、不适感较轻微.
목적 탐토병비교자체혈청적안액화소우혈거단백제취물안용응효재익상노육절제술후각막수복중적치료효과.방법 대2012년2월지2013년2월재무한시중심의원안과취진적60례익상노육환자행익상노육절제연합각막연우세포이식술,술후분별응용자체혈청적안액혹소우혈거단백제취물안용응효점안.술후수방3개월,관찰량충적안액재익상노육술후각막수복중적치료효과.결과 자체혈청적안액조술후3d시자각이물감、잡통등증상명현감경,4d시부유경도이물감;소우혈거단백제취물안용응효조술후4d시외광、류루개시감경,6d시이물감명현소실.각막상피평균수복시간자체혈청조(2.55±1.31)d,여소우혈거단백제취물안용응효조(3.55±1.23)d상비,차이유통계학의의(P＜0.05).술후시력회복량조대비차이무통계학의의(P＞0.05).수술치료후3개월,소유환자무감염、배척급기타병발증.결론 자체혈청적안액화소우혈거단백제취물안용응효균능유효지치료익상노육절제술후적각막상피결손,량자료효무명현차이.자체혈청적안액조환자술후상대회복교쾌,자각이물감、불괄감교경미.
Objective To compare the efficacy of autologous serum eye drops and deproteinized calf blood extract eye gel for corneal repair in the treatment of pterygium surgery.Methods A total of 60 cases (60 eyes) were received pterygium resection combined with limbal-conjunctival autografting.After surgery,they were randomly assigned to autologous serum eye drops (n =30) or deproteinized calf blood extract eye gel (n =30).Corneal wound healing,the presence or absence of conjunctival proliferation and hyperemia was analyzed at 3 months postoperatively.Results Patients received autologous serum eye drops felt less foreign body sensation,pain and other symptoms on the 3rd day and only mild foreign body sensation on the 4th day.In the extract eye gel group,photophobia and lacrimation began to ease after the 4th day; the foreign body sensation apparently disappeared on the 6th day.The Mean time of corneal epithelium repair were (2.55±1.31) days in the autologous serum group and (3.55±1.23) days in the deproteinized calf blood extract eye gel group,which showed significant difference (P ＜0.05).Visual acuity between the two groups showed no significant difference (P ＞0.05).Three months after surgery,there were no significant complications associated with the use of autologous serum eye drops or deproteinized calf blood extract eye gel including infection and rejection.Conclusions Both of the autologous serum eye drops and deproteinized calf blood extract eye gel are effective for comeal repair in the treatment of pterygium.Patients undergoing autologous serum eye drops experience faster recovery,less foreign body sensation and mild discomfort compared with those undergoing deproteinized calf blood extract eye gel.