CAJ | 학술논문

超导量子干涉仪利用约瑟夫森结宏观量子干涉效应，是一种具有超高灵敏度的磁通探测器件。对超导量子干涉仪的基本原理及其在低场核磁共振/成像技术中的应用进行了简要介绍，并报道了在这方面的主要研究成果。搭建了一套低场核磁共振及成像系统并获得具有较高信噪比的水样品1 H质子NMR谱及三氟乙醇的纯J-耦合谱，同时还测到了清晰的自旋回波信号。在此基础上，采用直接背投影重建方法，尝试并成功获得了水样品和生物样品的一维及二维核磁共振像。采用8 nm粒径的超顺磁Fe3 O4磁性纳米粒子作为对比增强剂，研究了磁性纳米粒子对1 H核自旋纵向弛豫时间 T1的影响，据此演示了磁性纳米粒子T1加权对比度增强成像实验，所得二维核磁共振像随极化时间的不同显示出显著的对比度变化。
초도양자간섭의이용약슬부삼결굉관양자간섭효응，시일충구유초고령민도적자통탐측기건。대초도양자간섭의적기본원리급기재저장핵자공진/성상기술중적응용진행료간요개소，병보도료재저방면적주요연구성과。탑건료일투저장핵자공진급성상계통병획득구유교고신조비적수양품1 H질자NMR보급삼불을순적순J-우합보，동시환측도료청석적자선회파신호。재차기출상，채용직접배투영중건방법，상시병성공획득료수양품화생물양품적일유급이유핵자공진상。채용8 nm립경적초순자Fe3 O4자성납미입자작위대비증강제，연구료자성납미입자대1 H핵자선종향이예시간 T1적영향，거차연시료자성납미입자T1가권대비도증강성상실험，소득이유핵자공진상수겁화시간적불동현시출현저적대비도변화。
Superconducting Quantum Interference Device ( SQUID) is a kind of ultra-sensitive flux detector based on macroscopic quantum interferencephenomenon of Josephson junctions .The principle of SQUID and advantages of its appli-cation in low-field nuclear magnetic resonance ( NMR) &imaging ( MRI) technologies are introduced, and some important experimental results are reported here .We built a low-field NMR&MRI system and obtained highly improved 1 H proton FID&Spin echo spectra.Pure J-coupling spectrum of 2, 2, 2-Trifluoroethyl was also measured and agreed well with high-field NMR results.In addition, we tried and successfully obtained 1D and 2D MRI images of water phantoms and bio-sam-ples.The influence of 8nm Fe3 O4 magnetic nanoparticles on longitudinal relaxation time of water was studied.Based on this property, we illustrated T1-contrast enhanced 2D imaging of water phantoms by using magnetic nanoparticles, which show evident contrast variation under different pre-polarization times.