CAJ | 학술논문

为探讨非酒精性脂肪肝（NAFLD）患者发生2型糖尿病的危险因素及脂肪肝的程度与血糖控制情况的相关性。选取2007年1月至2012年12月由福建医科大学附属第一医院内科收治的非酒精性脂肪肝患者149例，对伴初诊2型糖尿病组与单纯非酒精性脂肪肝组进行单因素和多因素的分析，探讨非酒精性脂肪肝患者发生2型糖尿病的危险因素。同时对88例非酒精性脂肪肝伴初诊2型糖尿病患者，根据脂肪肝超声分度，探讨其程度与血糖控制情况的相关性。结果显示，2型糖尿病的发生与糖尿病家族史、空腹血糖、血清空腹胰岛素、餐后2h胰岛素、甘油三酯、载脂蛋白A1有显著性关系。非酒精性脂肪肝伴2型糖尿病组的患者中，随着空腹血糖及糖基化血红蛋白值的升高，脂肪肝的程度加重,二者具有相关性（P<0.05）。故研究NAFLD患者发生2型糖尿病的危险因素，对早期干预和治疗糖尿病具有重要的临床意义。积极控制血糖，改善胰岛素抵抗，可延缓脂肪肝病程进展。
위탐토비주정성지방간（NAFLD）환자발생2형당뇨병적위험인소급지방간적정도여혈당공제정황적상관성。선취2007년1월지2012년12월유복건의과대학부속제일의원내과수치적비주정성지방간환자149례，대반초진2형당뇨병조여단순비주정성지방간조진행단인소화다인소적분석，탐토비주정성지방간환자발생2형당뇨병적위험인소。동시대88례비주정성지방간반초진2형당뇨병환자，근거지방간초성분도，탐토기정도여혈당공제정황적상관성。결과현시，2형당뇨병적발생여당뇨병가족사、공복혈당、혈청공복이도소、찬후2h이도소、감유삼지、재지단백A1유현저성관계。비주정성지방간반2형당뇨병조적환자중，수착공복혈당급당기화혈홍단백치적승고，지방간적정도가중,이자구유상관성（P<0.05）。고연구NAFLD환자발생2형당뇨병적위험인소，대조기간예화치료당뇨병구유중요적림상의의。적겁공제혈당，개선이도소저항，가연완지방간병정진전。
To explore risk factors of types 2 diabetes in patients with Nonalcoholic fatty liver disease, and stduy the association of fatty liver with blood glucose. 149 patients with Nonalcoholic fatty liver disease were selected from the first affiliated hospital, Fujian medical university from Jan. 2007 to Dec.2012. 88 cases of Nonalcoholic fatty liver disease with type 2 diabetes were enrol ed into study group.The control group were made of 61 cases of simple Nonalcoholic fatty liver disease. Al the factors were studied by statistical method of univariate and multivariate analysis. Then we can explore the risk factors of types 2 diabetes in patients with Nonalcoholic fatty liver disease. The family history of type 2 diabetes mel itus,fasting plasma glucose,fasting insulin,2h insulin, triglycerids, APOA1 were identified as the most important risk factors by multivariate analysis. In the study group,We can notice that with the increase of blood gluse and glyoosylated hemoglobin,the level of severity increased as wel .The severtiy was positive correlated to FBG and GHB.