中华行为医学与脑科学杂志
中華行為醫學與腦科學雜誌
중화행위의학여뇌과학잡지
CHINESE JOURNAL OF BEHAVIORAL MEDICINE AND BRAIN SCIENCE
2013年
12期
1089-1091
,共3页
无抽搐电休克治疗%精神分裂症%记忆
無抽搐電休剋治療%精神分裂癥%記憶
무추휵전휴극치료%정신분렬증%기억
Modified electroconvulsive therapy%Schizophrenia%Memory
目的 探讨无抽搐电休克治疗(MECT)对精神分裂症患者工作记忆的影响.方法 采用2-back工作记忆测试作为工作记忆批评定工具,对30例精神分裂症患者在MECT治疗前后的试验的正确率和反应时进行比较,同时比较精神分裂症患者中MECT组与30例单纯药物治疗精神分裂症患者在试验结果差异.结果 重复测量方差分析发现,MECT治疗前后3次试验正确率[(66.70±9.82)％,(67.61±6.83)％,(80.72± 12.08)％]和反应时[(1415.69±258.51)ms,(1328.65±236.08) ms,(1094.45±259.44) ms]差异具有统计学意义(F=19.163,P＜0.001;F=13.084,P＜0.001);精神分裂症患者在2-Back任务的正确率和反应时在MECT疗程结束后2周[(80.72± 12.08)％; (1094.45±259.44) ms]较MECT治疗前[(66.70±9.82)％;(1415.69±258.51) ms]均有提高,差异有统计学意义(t=-4.369,P＜0.001;t=5.596,P＜0.001);精神分裂症患者在MECT疗程结束后2周[(80.72± 12.08)％;(1094.45± 259.44) ms]较MECT疗程结束后1d[(67.61±6.83)％;(1328.65±236.081) ms]均有提高,差异有统计学意义(t=-5.416,P＜0.000;t=3.824,P=0.001);MECT组精神分裂症患者在疗程结束2周在试验正确率方面大于服药组[(73.67± 10.41)％],差异有统计学意义(t=2.424,P=0.018).结论 精神分裂症患者工作记忆功能经过MECT治疗可能会有不同程度的改善.
目的 探討無抽搐電休剋治療(MECT)對精神分裂癥患者工作記憶的影響.方法 採用2-back工作記憶測試作為工作記憶批評定工具,對30例精神分裂癥患者在MECT治療前後的試驗的正確率和反應時進行比較,同時比較精神分裂癥患者中MECT組與30例單純藥物治療精神分裂癥患者在試驗結果差異.結果 重複測量方差分析髮現,MECT治療前後3次試驗正確率[(66.70±9.82)％,(67.61±6.83)％,(80.72± 12.08)％]和反應時[(1415.69±258.51)ms,(1328.65±236.08) ms,(1094.45±259.44) ms]差異具有統計學意義(F=19.163,P＜0.001;F=13.084,P＜0.001);精神分裂癥患者在2-Back任務的正確率和反應時在MECT療程結束後2週[(80.72± 12.08)％; (1094.45±259.44) ms]較MECT治療前[(66.70±9.82)％;(1415.69±258.51) ms]均有提高,差異有統計學意義(t=-4.369,P＜0.001;t=5.596,P＜0.001);精神分裂癥患者在MECT療程結束後2週[(80.72± 12.08)％;(1094.45± 259.44) ms]較MECT療程結束後1d[(67.61±6.83)％;(1328.65±236.081) ms]均有提高,差異有統計學意義(t=-5.416,P＜0.000;t=3.824,P=0.001);MECT組精神分裂癥患者在療程結束2週在試驗正確率方麵大于服藥組[(73.67± 10.41)％],差異有統計學意義(t=2.424,P=0.018).結論 精神分裂癥患者工作記憶功能經過MECT治療可能會有不同程度的改善.
목적 탐토무추휵전휴극치료(MECT)대정신분렬증환자공작기억적영향.방법 채용2-back공작기억측시작위공작기억비평정공구,대30례정신분렬증환자재MECT치료전후적시험적정학솔화반응시진행비교,동시비교정신분렬증환자중MECT조여30례단순약물치료정신분렬증환자재시험결과차이.결과 중복측량방차분석발현,MECT치료전후3차시험정학솔[(66.70±9.82)％,(67.61±6.83)％,(80.72± 12.08)％]화반응시[(1415.69±258.51)ms,(1328.65±236.08) ms,(1094.45±259.44) ms]차이구유통계학의의(F=19.163,P＜0.001;F=13.084,P＜0.001);정신분렬증환자재2-Back임무적정학솔화반응시재MECT료정결속후2주[(80.72± 12.08)％; (1094.45±259.44) ms]교MECT치료전[(66.70±9.82)％;(1415.69±258.51) ms]균유제고,차이유통계학의의(t=-4.369,P＜0.001;t=5.596,P＜0.001);정신분렬증환자재MECT료정결속후2주[(80.72± 12.08)％;(1094.45± 259.44) ms]교MECT료정결속후1d[(67.61±6.83)％;(1328.65±236.081) ms]균유제고,차이유통계학의의(t=-5.416,P＜0.000;t=3.824,P=0.001);MECT조정신분렬증환자재료정결속2주재시험정학솔방면대우복약조[(73.67± 10.41)％],차이유통계학의의(t=2.424,P=0.018).결론 정신분렬증환자공작기억공능경과MECT치료가능회유불동정도적개선.
Objective To explore the effect of modified electroconvulsive therapy (MECT) on working memory in schizophrenia patients.Methods 2-back test paradigm was set to measure the performances of working memory.A total of 30 cases of schizophrenia were recruited and measured with accurate rate and reaction time on this tasks before and after treatment with MECT.Differences were analyzed between patients through MECT treatment and 30 patients through drug treatment.Results Repeated measure ment analysis of variance on the accurate rate ((66.70±9.82) ％,(67.61±6.83) ％,(80.72± 12.08) ％) and reaction time((1415.69± 258.51) ms,(1328.65±236.08) ms,(1094.45± 259.44) ms) of 2-back test were significant among three times of MECT (F=19.163,P＜0.001 ; F=13.084,P＜0.001).Schizophrenia patient's performance of error rate and reaction time of 2-back test were higher at the end of 2 weeks after treatment((80.72± 12.08)％;(1094.45± 259.44)ms) than before MECT treatment ((66.70±9.82) ％ ; (1415.69±258.51) ms).The difference between them were significant(t =-4.369,P＜0.001 ; t=5.596,P＜0.001).Schizophrenia patients performance of error rate and reaction time of 2-back test were higher at the end of 2 weeks after treatment((80.72± 12.08)％;(1094.45±259.44) ms) than at the end of 1 day after treatment((67.61±6.83)％;(1328.65±236.08) ms).The difference between them were significant(t=-5.416,P＜0.000; t=3.824,P=0.001).Schizophrenia patients performance of error rate of 2-back test were higher at the end of 2 weeks after treatment than drug treatment group ((73.67±10.41) ％),and the difference between them were significant(t=2.424,P=0.018).Conclusion Working memory functions in schizophrenia patients may be improved in varying degrees with MECT.
