中外医学研究
中外醫學研究
중외의학연구
CHINESE AND FOREIGN MEDICAL RESEARCH
2013年
36期
40-41
,共2页
胰岛素%口服降糖药%2型糖尿病
胰島素%口服降糖藥%2型糖尿病
이도소%구복강당약%2형당뇨병
Insulin%Hypoglycemic agents%Type 2 diabetes
目的：探讨甘精胰岛素联合不同口服降糖药治疗老年糖尿病的临床疗效及安全性。方法：将笔者所在医院收治的93例2型糖尿病老年患者按照分层随机分组法分为观察组与对照组，对照组给予甘精胰岛素+罗格列酮治疗，观察组给予甘精胰岛素+那格列奈治疗，观察两组糖化血红蛋白(HbA1c)、空腹血糖(FBG)、餐后2 h血糖(2 h PG)控制情况，同时观察低血糖发生率、血糖达标天数及胰岛素用量。结果：观察组血糖达标天数为(5.1±1.3)d，低血糖发生率为12.5％(7/56)，对照组血糖达标天数为(8.3±1.5)d，低血糖发生率为32.4％(12/37)，两组比较差异有统计学意义(P<0.05)；观察组HbA1c及2 h PG控制情况也显著优于对照组，两组比较差异有统计学意义(P<0.05)。结论：胰岛素联合非磺酰脲类促胰岛素分泌剂那格列奈，能较好控制餐后血糖及降低低血糖发生率，具有重要临床应用价值。
目的：探討甘精胰島素聯閤不同口服降糖藥治療老年糖尿病的臨床療效及安全性。方法：將筆者所在醫院收治的93例2型糖尿病老年患者按照分層隨機分組法分為觀察組與對照組，對照組給予甘精胰島素+囉格列酮治療，觀察組給予甘精胰島素+那格列奈治療，觀察兩組糖化血紅蛋白(HbA1c)、空腹血糖(FBG)、餐後2 h血糖(2 h PG)控製情況，同時觀察低血糖髮生率、血糖達標天數及胰島素用量。結果：觀察組血糖達標天數為(5.1±1.3)d，低血糖髮生率為12.5％(7/56)，對照組血糖達標天數為(8.3±1.5)d，低血糖髮生率為32.4％(12/37)，兩組比較差異有統計學意義(P<0.05)；觀察組HbA1c及2 h PG控製情況也顯著優于對照組，兩組比較差異有統計學意義(P<0.05)。結論：胰島素聯閤非磺酰脲類促胰島素分泌劑那格列奈，能較好控製餐後血糖及降低低血糖髮生率，具有重要臨床應用價值。
목적：탐토감정이도소연합불동구복강당약치료노년당뇨병적림상료효급안전성。방법：장필자소재의원수치적93례2형당뇨병노년환자안조분층수궤분조법분위관찰조여대조조，대조조급여감정이도소+라격렬동치료，관찰조급여감정이도소+나격렬내치료，관찰량조당화혈홍단백(HbA1c)、공복혈당(FBG)、찬후2 h혈당(2 h PG)공제정황，동시관찰저혈당발생솔、혈당체표천수급이도소용량。결과：관찰조혈당체표천수위(5.1±1.3)d，저혈당발생솔위12.5％(7/56)，대조조혈당체표천수위(8.3±1.5)d，저혈당발생솔위32.4％(12/37)，량조비교차이유통계학의의(P<0.05)；관찰조HbA1c급2 h PG공제정황야현저우우대조조，량조비교차이유통계학의의(P<0.05)。결론：이도소연합비광선뇨류촉이도소분비제나격렬내，능교호공제찬후혈당급강저저혈당발생솔，구유중요림상응용개치。
Objective:To explore the clinical efficacy and safety of Insulin combined with the different oral hypoglycemic agents in the treatment of elderly patients with diabetes.Method:According to a stratified randomization method,93 cases of elderly patients with type 2 diabetes were divided into the observation group and the control group in our hospital,the control group were given insulin glargine and rosiglitazone,the observation group were given insulin glargine and nateglinide,two groups of HbA1c,FBG,2 h PG,the incidence of hypoglycemia,recovering time of blood glucose and insulin dosage were observed. Result:The blood glucose up to normal levels of time was (5.1±1.3)d in the observation group and (8.3±1.5)d in the control group(P<0.05),the incidence of hypoglycemia was 12.5%(7/56) in the observation group and 32.4%(12/37) in the control group(P<0.05),the observation group was significantly better than the control group in HbA1c and 2 h PG,the difference was statistically significant(P<0.05).Conclusion:Insulin combined nateglinide can significantly reduce the incidence of hypoglycemia and control the postprandial glucose levels,it has important clinical value.
