CAJ | 학술논문

目的探讨脑脊液净化系统临床应用的性能及用于治疗自发性蛛网膜下腔出血的有效性、安全性，初步评价其临床应用价值。方法治疗组及对照组患者各20例，入院后均行DSA检查明确出血原因为动脉瘤，经神经介入治疗病情稳定后同时采用脱水、止血、抑酸、抑制血管痉挛、镇静止痛、血压控制及防治感染等对症支持治疗21 d。治疗组患者通过腰椎穿刺置管连接脑脊液净化系统，连续治疗3d，8次/d，将脑室和蛛网膜下腔内的血性脑脊液分次引流排出。结果两组根据CT影像学变化、脑血管痉挛缓解时间、脑脊液中红细胞数的变化、临床症状的改善情况等进行比较，结果显示治疗组疗效优于对照组（P＜0．05）。结论脑脊液净化系统治疗动脉瘤性蛛网膜下腔出血的疗效较显著，可较快减少颅腔内出血量，较早缓解血管痉挛，减轻临床症状。
목적탐토뇌척액정화계통림상응용적성능급용우치료자발성주망막하강출혈적유효성、안전성，초보평개기림상응용개치。방법치료조급대조조환자각20례，입원후균행DSA검사명학출혈원인위동맥류，경신경개입치료병정은정후동시채용탈수、지혈、억산、억제혈관경련、진정지통、혈압공제급방치감염등대증지지치료21 d。치료조환자통과요추천자치관련접뇌척액정화계통，련속치료3d，8차/d，장뇌실화주망막하강내적혈성뇌척액분차인류배출。결과량조근거CT영상학변화、뇌혈관경련완해시간、뇌척액중홍세포수적변화、림상증상적개선정황등진행비교，결과현시치료조료효우우대조조（P＜0．05）。결론뇌척액정화계통치료동맥류성주망막하강출혈적료효교현저，가교쾌감소로강내출혈량，교조완해혈관경련，감경림상증상。
Objective To investigate the curative effect and safety of cerebrospinal fluid (CSF) purification system in treatment for the patients with aneurgsmal subarachnoid hemorrhage .Methods The lumbar puncture cerebrospinal fluid purification system was connected ,fluid purification treat-ment in accordance with conventional treatment for 3 days ,the ventricles and subarachnoid cerebrospi-nal fluid within the sub-sub-drainage of bloody discharge ,in order to achieve lower intracranial pres-sure and reduce cerebral vasospasm ,reduce the adhesion and AGs of communicating hydrocephalus oc-curred purposes .Results After treatment ,reduce the time Fisher classification was that treatment group was (1 .7 ± 1 .9) d ,P<0 .05 ,and control group was (4 .4 ± 1 .2) d ,P<0 .05 .Cerebral vas-ospasm (CVS) duration of response was that treatment group was (4 .2 ± 1 .5) d ,P< 0 .05 ,and in control group was (10 .4 ± 1 .7) d ,P<0 .05 .CSF red blood cell count returned to normal hours was that treatment group was (9 .7 ± 1 .8) d ,P< 0 .05 ,and control group was (14 .2 ± 1 .4) d ,P<0 .05 .Delayed ischemic neurological deficit (DIND) duration of response was that treatment group was (10 .2 ± 1 .9) d ,P<0 .05 ,and control group was (17 .4 ± 1 .3) d ,P<0 .05 .mRS grade reduc-tion time was that treatment group was (9 .3 ± 1 .7) d ,P<0 .05 ,and control group was (13 .0 ± 1 .4) d ,P<0 .05 .The headache duration of response was that treatment group was (7 .1 ± 1 .4) d ,P<0 .05 ,and control group was (14 .2 ± 1 .6) d ,P<0 .05 .Then the incidence of bleeding and death were no significant differences (P> 0 .05) ,the total effective than the control group (chi-square value was 6 .144 ,P< 0 .05 .Conclusion The treatment of CSF purification system is an effective and safe method for the patients with aneurismal subarachnoid hemorrhage .