CAJ | 학술논문

目的：探讨依达拉奉对急性一氧化碳中毒迟发性脑病（DEACMP）患者血清神经元特异性烯醇化酶（NSE）、超氧化物歧化酶（SOD）的影响。方法将DEACMP患者46例随机分为观察组和对照组，各23例，对照组给予高压氧及胞磷胆碱钠注射液等常规治疗，观察组在常规治疗基础上给予依达拉奉注射液30mg静脉滴注，2次/d，治疗14d。在治疗前及治疗后第3、7、14天，利用酶联免疫吸附法检测患者血清NSE浓度，用黄嘌呤氧化酶法检测患者血清SOD浓度及在治疗前、治疗后第14天做简易智能精神量表（MMSE）评分，进行比较。结果观察组有效率90.3%，对照组65.3%；观察组患者血清NSE浓度明显下降，低于对照组（P<0.05），SOD浓度升高，高于对照组（P<0.05）；观察组MMSE评分改善优于对照组（P<0.05），结论依达拉奉注射液可以有效降低DEACMP患者血清NSE浓度，提高SOD活性，对DEACMP有较好疗效。
목적：탐토의체랍봉대급성일양화탄중독지발성뇌병（DEACMP）환자혈청신경원특이성희순화매（NSE）、초양화물기화매（SOD）적영향。방법장DEACMP환자46례수궤분위관찰조화대조조，각23례，대조조급여고압양급포린담감납주사액등상규치료，관찰조재상규치료기출상급여의체랍봉주사액30mg정맥적주，2차/d，치료14d。재치료전급치료후제3、7、14천，이용매련면역흡부법검측환자혈청NSE농도，용황표령양화매법검측환자혈청SOD농도급재치료전、치료후제14천주간역지능정신량표（MMSE）평분，진행비교。결과관찰조유효솔90.3%，대조조65.3%；관찰조환자혈청NSE농도명현하강，저우대조조（P<0.05），SOD농도승고，고우대조조（P<0.05）；관찰조MMSE평분개선우우대조조（P<0.05），결론의체랍봉주사액가이유효강저DEACMP환자혈청NSE농도，제고SOD활성，대DEACMP유교호료효。
Objective TO Investigate the effect of Edaravone on content of serum NSE、SOD in delayed encephalopathy after acute carbon monoxide poisoning. Methods 46 patients with DEACMP were divided into two groups randomly.Both the groups were treated with normal method and the treatment group was given edaravone 30mg,twice a day, total of 14d.The serum levers of NSE、SOD were measured by ELISA、Xanthine oxidase from buttermilk before treatment and at the time of 3,7,14d.MMSE were measured before treatment and 14d after treatment. Results The serum levers of NSE of Edaravone group was lower than of contral group(P<0.05). The serum levers of SOD and MMSE scores of Edaravone group were higher than of contral group(P<0.05). Conclusion Edaravone may protect against DEACMP.