CAJ | 학술논문

目的：本研究通过应用三维适形放疗加热疗及抗骨质疏松药物的综合治疗100例宫颈癌伴绝经患者，探讨综合治疗的可行性和优越性，以改进临床工作，提高肿瘤患者的生活质量和疗效。预防和延迟骨质疏松的发生。方法将100例宫颈癌患者分为三维适形放疗加热疗及抗骨质疏松药物组50例（ R＋H＋OP）和单纯三维适形放疗组50例（ R）。治疗过程中观察不良反应，治疗结束后一个月评价疗效。结果宫颈癌伴绝经患者与对照组相比BGP、BMD均明显降低， P＜0.01、P ＜0.001；AKP升高，两者比较有明显差异，P ＜0.05；血Ca、P无明显变化，P ＞0.05。结论对中晚期宫颈癌伴绝经患者用三维适形放疗加热疗及抗骨质疏松药物综合治疗的同时，测定BGP、BMD、AKP等具有临床价值。为进一步提高患者的生活质量必须采取适当的治疗和预防措施，以降低恶性肿瘤的骨转移及其引起的骨破坏，有针对性的选择适形放疗热疗及抗骨质疏松药物等同时对肿瘤引起的骨破坏或继发病症进行治疗和预防，以减轻症状和防止严重并发症的发生。
목적：본연구통과응용삼유괄형방료가열료급항골질소송약물적종합치료100례궁경암반절경환자，탐토종합치료적가행성화우월성，이개진림상공작，제고종류환자적생활질량화료효。예방화연지골질소송적발생。방법장100례궁경암환자분위삼유괄형방료가열료급항골질소송약물조50례（ R＋H＋OP）화단순삼유괄형방료조50례（ R）。치료과정중관찰불량반응，치료결속후일개월평개료효。결과궁경암반절경환자여대조조상비BGP、BMD균명현강저， P＜0.01、P ＜0.001；AKP승고，량자비교유명현차이，P ＜0.05；혈Ca、P무명현변화，P ＞0.05。결론대중만기궁경암반절경환자용삼유괄형방료가열료급항골질소송약물종합치료적동시，측정BGP、BMD、AKP등구유림상개치。위진일보제고환자적생활질량필수채취괄당적치료화예방조시，이강저악성종류적골전이급기인기적골파배，유침대성적선택괄형방료열료급항골질소송약물등동시대종류인기적골파배혹계발병증진행치료화예방，이감경증상화방지엄중병발증적발생。
Objective To investigate the feasibility and the advantage of comprehensive therapy , which composed of 3D CRT, hyperthermia , and anti-osteoporosis medicine , for cervical cancer in 100 patients, to improve clinical work and the quality of life of the patients , and to prevent and delay the occurrence of osteoporosis .Methods A total of 100 cervical cancer patients were divided into 2 groups (n=50, each).Patients in Group A were treated with three dimensional conformal radiotherapy , hyperthermia, and drug resistance of bone hydrophobic ( A: R +H +OP ) , while patients in Group B were just treated with three-dimensional conformal radiotherapy ( B:R) .The adverse reactions of the treatment were observed .The efficacy was evaluated 1 month after the treatment . Results The level of BGP and BMD in Group A was significantly lower than that in Group B (P<0.01, P<0.001).The AKP level increased (P<0.05).No significant difference of calcium and phosphorus was observed between 2 groups (P>0.05).Conclusion Targeted selection of comprehensive therapy , including conformal radiotherapy , hyperthermia , and anti-osteoporosis medicine , can prevent and treat the bone destruction and secondary diseases caused by the tumor , which can relieve the symptoms and prevent the occurrence of serious complications .