CAJ | 학술논문

目的：对急性肺损伤保护性通气加乌司他丁可以改善肺的呼吸功能，降低患者病死率的作用效果进行探讨和分析。方法：选取2011年3月至2013年3月我院收治的急性肺损伤患者82例，作为研究的对象，并将这82名急性肺损伤的患者随机分为肺保护性通气组和肺保护性通气加乌司他丁组，每组各41名患者。肺保护性通气组在对患者进行保护性通气治疗的基础上根据病情进行综合治疗。对肺保护性通气加乌司他丁组在肺保护性通气组治疗的基础上予以乌司他丁20万U每100ml盐水静滴，每日2次，每6天为一个疗程。对反映两组患者肺呼吸功能的动脉血气分析的各项指标的改变进行观察，并对住院期间ICU患者的死亡人数进行记录，并计算两组患者的病死率。结果：肺保护性通气加乌司他丁组的患者的PaO2以及氧合指数明显高于肺保护性通气组(P<0.05)。肺保护性通气加乌司他丁组的患者的住院时间(20±9)天比肺保护性通气组的(34±11)天明显缩短(P<0.05)，肺保护性通气加乌司他丁组的患者的死亡率(24.39%)比肺保护性通气组的(51.22%)明显降低(P<0.05)，差异有统计学意义。结论：急性肺损伤保护性通气加乌司他丁可以改善肺的呼吸功能，降低患者病死率。
목적：대급성폐손상보호성통기가오사타정가이개선폐적호흡공능，강저환자병사솔적작용효과진행탐토화분석。방법：선취2011년3월지2013년3월아원수치적급성폐손상환자82례，작위연구적대상，병장저82명급성폐손상적환자수궤분위폐보호성통기조화폐보호성통기가오사타정조，매조각41명환자。폐보호성통기조재대환자진행보호성통기치료적기출상근거병정진행종합치료。대폐보호성통기가오사타정조재폐보호성통기조치료적기출상여이오사타정20만U매100ml염수정적，매일2차，매6천위일개료정。대반영량조환자폐호흡공능적동맥혈기분석적각항지표적개변진행관찰，병대주원기간ICU환자적사망인수진행기록，병계산량조환자적병사솔。결과：폐보호성통기가오사타정조적환자적PaO2이급양합지수명현고우폐보호성통기조(P<0.05)。폐보호성통기가오사타정조적환자적주원시간(20±9)천비폐보호성통기조적(34±11)천명현축단(P<0.05)，폐보호성통기가오사타정조적환자적사망솔(24.39%)비폐보호성통기조적(51.22%)명현강저(P<0.05)，차이유통계학의의。결론：급성폐손상보호성통기가오사타정가이개선폐적호흡공능，강저환자병사솔。
Objective:To study and discuss the improvement effect of lung respiratory function and the reduction effect of the patients mortality by using lung protective ventilation and ulinastatin to treat acute lung injury.Methods:82 patients with acute lung injury who received the treatment in our hospital from March 2011to March 2013 were selected as research objects, and they were randomly divided into two groups:the group of lung protective ventilation (41 patients) and the group of lung protective ventilation plus ulinastatin (41 patients). Patients in the group of lung protective ventilation received the comprehensive treatment on the basis of the treatment of protective ventilation.Patients in the group of lung protective ventilation plus ulinastatin had an intravenous drip of ulinastatin (200,000 U with 100 ml saline solution, 2 times per day, 6 days of a course) on the basis of the treatment of protective ventilation. Arterial blood gas index changes of the lung respiratory function for patients in the two groups were observed and analyzed;the death toll of ICU patients during hospitalization was recorded, and the case fatality rates for patients in the two groups were calculated.Results:Indexes of PaO and oxygenation for patients in the group of lung protective ventilation plus ulinastatin were significantly higher than that of the patients in the group of lung protective ventilation (P<0.05). The hospital stays for patients in the group of lung protective ventilation plus ulinastatin (20±9 days) were significantly shorter than that of the patients in the group of lung protective ventilation(34±11), (P<0.05). The case fatality rate for patients in the group of lung protective ventilation plus ulinastatin (24.39%) was significantly lower than that of the patients in the group of lung protective ventilation (51.22%), (P<0.05). The differences were of statistically significance.Conclusion:The treatment of protective ventilation plus ulinastatin for acute lung injury can improve the respiratory function of lung and decrease the case fatality rate.