CAJ | 학술논문

目的：探讨两种剂量辛伐他汀对脑梗死的临床治疗效果,并分析其药理作用。方法：我院在2010年10月至2013年3月期间共接诊脑梗死患者150例,将其随机分成实验组(75例)和对照组(75例),两组均给予常规基础治疗,在此基础上对照组给予辛伐他汀(20毫克/天),实验组(40毫克/天),均在睡前顿服,连续治疗一疗程(12周)。对比分析两组的DNS评分、临床疗效及不良反应等。结果：两组在治疗前DNS评分无明显差异(P>0.05),在治疗后实验组的DNS评分为(9.15±4.33)分显著低于对照组(14.31±3.92)分,两组差异比较有统计学意义(t=7.1170,P<0.01)。实验组治疗有效率为94.67%,显著高于对照组(81.33%),两组差异比较有统计学意义(X2=7.1932,P<0.05)。两组均未出现严重不良反应,且不良反应发生率无明显差异(P>0.05)。结论：在常规治疗的基础上,给予大剂量的辛伐他汀可显著降低神经功能的缺损程度,提高治疗效果,同时不良反应反应发生率无明显提高,因此应在临床中推广应用。
목적：탐토량충제량신벌타정대뇌경사적림상치료효과,병분석기약리작용。방법：아원재2010년10월지2013년3월기간공접진뇌경사환자150례,장기수궤분성실험조(75례)화대조조(75례),량조균급여상규기출치료,재차기출상대조조급여신벌타정(20호극/천),실험조(40호극/천),균재수전돈복,련속치료일료정(12주)。대비분석량조적DNS평분、림상료효급불량반응등。결과：량조재치료전DNS평분무명현차이(P>0.05),재치료후실험조적DNS평분위(9.15±4.33)분현저저우대조조(14.31±3.92)분,량조차이비교유통계학의의(t=7.1170,P<0.01)。실험조치료유효솔위94.67%,현저고우대조조(81.33%),량조차이비교유통계학의의(X2=7.1932,P<0.05)。량조균미출현엄중불량반응,차불량반응발생솔무명현차이(P>0.05)。결론：재상규치료적기출상,급여대제량적신벌타정가현저강저신경공능적결손정도,제고치료효과,동시불량반응반응발생솔무명현제고,인차응재림상중추엄응용。
Objective:To discuss the efect of two doses of simvastatin on treatment of cerebral infarction, and analyzes its pharmacological. Methods:There were 150 cases with cerebral infarction, randomly divided into experimental group (75 cases) and control group (75 cases), all were given conventional foundation treatment, then the control group was given simvastatin (20 mg/day), the experimental group (40 mg/day), 12 weeks for a course. Compare DNS grading, clinical efficacy and adverse reactions between the two groups.Results:Before treatment, the DNS between the two groups had no difference (P>0.05), after treatment, the DNS in experimental group(9.15±4.33) is significantly lower than it in control group (14.31±3.92)(P<0.01). The effective rate in experimental group was 94.67%, significantly higher than that of control group (81.33%) (P<0.05). No severe adverse reaction occurred in both groups, and the incidence of adverse drug reactions have no obvious difference (P>0.05).Conclusion:on the basis of routine treatment, large doses of simvastatin can significantly reduce the degree of nerve function defect, improve the effect of treatment, the incidence of adverse reactions have no obvious increase at the same time, so it should be applied in clinical.