CAJ | 학술논문

目的：探讨联合应用胞磷胆碱钠与石杉碱甲治疗血管性痴呆的临床疗效。方法：选取我院2011年9月~2012年12月间收治的血管性痴呆患者164例,随机分为对照组和治疗组,在常规治疗和护理基础上,对照组采用石杉碱甲片治疗,观察组患者采用胞磷胆碱钠片与石杉碱甲片联合治疗,比较分析两组患者临床疗效及治疗前后MMSE、ADL评分。结果：治疗六个疗程后,治疗组总有效率高于对照组,但两组进行比较差异无统计学意义(P>0.05)。治疗前,对照组和治疗组患者MMSE、ADL评分无显著差异(P>0.05),治疗后,两组患者分别与治疗前对比,MMSE、ADL评分均呈现出显著性差异(P<0.05),两组治疗后MMSE、ADL评分进行对比,差异显著(P<0.05)。两组患者治疗期间均有轻度不良反应发生,但均自行消失,未影响继续治疗。讨论：胞磷胆碱钠联合石杉碱甲对血管性痴呆患者的治疗安全有效,具有较好的临床推广应用价值。
목적：탐토연합응용포린담감납여석삼감갑치료혈관성치태적림상료효。방법：선취아원2011년9월~2012년12월간수치적혈관성치태환자164례,수궤분위대조조화치료조,재상규치료화호리기출상,대조조채용석삼감갑편치료,관찰조환자채용포린담감납편여석삼감갑편연합치료,비교분석량조환자림상료효급치료전후MMSE、ADL평분。결과：치료륙개료정후,치료조총유효솔고우대조조,단량조진행비교차이무통계학의의(P>0.05)。치료전,대조조화치료조환자MMSE、ADL평분무현저차이(P>0.05),치료후,량조환자분별여치료전대비,MMSE、ADL평분균정현출현저성차이(P<0.05),량조치료후MMSE、ADL평분진행대비,차이현저(P<0.05)。량조환자치료기간균유경도불량반응발생,단균자행소실,미영향계속치료。토론：포린담감납연합석삼감갑대혈관성치태환자적치료안전유효,구유교호적림상추엄응용개치。
Objective:To explore the clinical therapeutic effect of combined use of citicoline sodium and huperzine A in the treatment of vascular dementia.Methods:164 patients with vascular dementia were selected in our hospital from 2011 September~2012 year in December between the treated patients, were randomly divided into control group and treatment group, on the basis of routine treatment and nursing, the control group using huperzine A tablets in the treatment, the observation group were treated with citicoline sodium tablets and huperzine A tablets combined treatment, comparison and analysis of MMSE, ADL score before and after the two groups of patients with clinical curative effect and treatment.Results:after six courses of treatment, the total effective rate in treatment group than in the control group, but the two groups had no significant difference (P>0.05). Before treatment, the treatment group and the control group of patients with MMSE, the ADL score had no significant difference (P>0.05), after treatment, two groups of patients were compared with before treatment, MMSE score, ADL showed significant difference (P<0.05), the two groups after treatment MMSE, ADL scores were compared, difference was significant (P<0.05). Two groups of patients with mild adverse reactions have occurred, but it disappeared, no influence to treatment.Conclusion:Citicoline sodium combined with huperzine A on vascular dementia patients is safe and effective for treatment, has a good clinical application value.