激光杂志
激光雜誌
격광잡지
LASER JOURNAL
2012年
3期
55-57
,共3页
玻璃酸钠%中药熏洗%膝关节骨关节炎%疗效%Meta分析
玻璃痠鈉%中藥熏洗%膝關節骨關節炎%療效%Meta分析
파리산납%중약훈세%슬관절골관절염%료효%Meta분석
sodium hyalurormte%herbal fumigation%knee osteoarthritis%RCT%meta-analysis
背景：国内应用玻璃酸钠配合中药熏洗治疗膝关节骨关节炎较为广泛，但临床研究报道多为小样本随机对照研究，缺乏循证医学方面的依据和说服力。目的：对应用玻璃酸钠配合中药熏洗治疗膝关节骨关节炎的疗效进行系统评价。方法：计算机检索Pubmed、Sciencedirect（so）数据库、重庆维普中文科技期刊全文数据库（VIP，1989／2010）和清华同方数据库（CNKI，1979／2010），收集有关关节腔内注射玻璃酸钠配合中药熏洗与单独使用玻璃酸钠治疗膝关节骨关节炎相比较的随机对照实验（RCT）。评价纳入研究的方法学质量并进行资料提取后，采用RevMan5．1软件进行Meta分析。结果：共纳入18个RCT，包括2312例膝关节骨关节炎患者。Meta分析结果显示：治疗后玻璃酸钠配合中药熏洗组总有效率均高于单独使用玻璃酸钠组。结论：在改善膝关节功能方面，玻璃酸钠配合中药熏洗治疗效果远高于对照组；但在远期疗效方面优势不甚明显，尚需大样本高质量随机对照研究去进一步证实。
揹景：國內應用玻璃痠鈉配閤中藥熏洗治療膝關節骨關節炎較為廣汎，但臨床研究報道多為小樣本隨機對照研究，缺乏循證醫學方麵的依據和說服力。目的：對應用玻璃痠鈉配閤中藥熏洗治療膝關節骨關節炎的療效進行繫統評價。方法：計算機檢索Pubmed、Sciencedirect（so）數據庫、重慶維普中文科技期刊全文數據庫（VIP，1989／2010）和清華同方數據庫（CNKI，1979／2010），收集有關關節腔內註射玻璃痠鈉配閤中藥熏洗與單獨使用玻璃痠鈉治療膝關節骨關節炎相比較的隨機對照實驗（RCT）。評價納入研究的方法學質量併進行資料提取後，採用RevMan5．1軟件進行Meta分析。結果：共納入18箇RCT，包括2312例膝關節骨關節炎患者。Meta分析結果顯示：治療後玻璃痠鈉配閤中藥熏洗組總有效率均高于單獨使用玻璃痠鈉組。結論：在改善膝關節功能方麵，玻璃痠鈉配閤中藥熏洗治療效果遠高于對照組；但在遠期療效方麵優勢不甚明顯，尚需大樣本高質量隨機對照研究去進一步證實。
배경：국내응용파리산납배합중약훈세치료슬관절골관절염교위엄범，단림상연구보도다위소양본수궤대조연구，결핍순증의학방면적의거화설복력。목적：대응용파리산납배합중약훈세치료슬관절골관절염적료효진행계통평개。방법：계산궤검색Pubmed、Sciencedirect（so）수거고、중경유보중문과기기간전문수거고（VIP，1989／2010）화청화동방수거고（CNKI，1979／2010），수집유관관절강내주사파리산납배합중약훈세여단독사용파리산납치료슬관절골관절염상비교적수궤대조실험（RCT）。평개납입연구적방법학질량병진행자료제취후，채용RevMan5．1연건진행Meta분석。결과：공납입18개RCT，포괄2312례슬관절골관절염환자。Meta분석결과현시：치료후파리산납배합중약훈세조총유효솔균고우단독사용파리산납조。결론：재개선슬관절공능방면，파리산납배합중약훈세치료효과원고우대조조；단재원기료효방면우세불심명현，상수대양본고질량수궤대조연구거진일보증실。
Backgrotmd： Sedium hyaluronate with herbal fumigation is widely used in the treatment of knee osteoarthritis, and many articles have confirmed the effectiveness of it. However the deficient number of eases impacts the credibility of the articles and relevant evidence - based medicine studies are rare. Objective： To assess the effectiveness of sodium hyaluronate with herbal fumigation for treating knee ostcoarthritis in clinical study. Methods： We searched Pubmed, Science direct（SD）, VIP（ 1989 to 2010）and CNKI（ 1979 to 2010）. Randomized controlled trials （RCTs） about sodium hyaluronate with herbal fumigation in the treatment of knee osteoarttn-itis were collected. The methodological quality of the included studies was evaluated, and data analyses were performed using the Cochrane Collaboration＇ s software RevMan 5.1. Results： A total of 18 RCTs involving 2312 patients were included. A descriptive analysis of the results was presented： The effectiveness of observation group was better to control group obviously. Conclusions： There was also a significant difference between the two therapies in improvement of ftmction of the knee joint. But there were no obvious advantages in long term effects, it still needs a large sample of high - quality randomized controlled studies to be further confirmed.
