CAJ | 학술논문

以硫氰酸红霉素为起始原料，通过控制反应体系的pH以及温度条件，高转化率高选择性地合成红霉素A肟，硫氰酸红霉素的转化率可达98％以上，主要副产物（Z）-红霉素A肟可控制在1．5％以下，确立了最佳工艺条件，已实现工业化并取得良好经济效果。
이류청산홍매소위기시원료，통과공제반응체계적pH이급온도조건，고전화솔고선택성지합성홍매소A우，류청산홍매소적전화솔가체98％이상，주요부산물（Z）-홍매소A우가공제재1．5％이하，학립료최가공예조건，이실현공업화병취득량호경제효과。
With erythromyein thioeyanate as starting material , by controlling the systems pH value and reaction temperature , high transform and high selectivity synthesize the erythromycin A oxime. Erythromyein thiocyanate conversion rate was over 98%. the main outgrowth was below 1.5%. under the optimal conditions. Realized industrialization （Z） - erythromycin A oxime and obtained good economic