CAJ | 학술논문

二吲哚基甲烷具有特别的生理活性，是一种很好的抗癌药物。固体酸氨基磺酸做催化剂，吲哚与醛、酮反应合成了一系列二吲哚基烷烃。对溶剂，温度，反应时间等工艺条件进行了探讨，优化条件为：水做溶剂，温度30～40℃，反应时间3h，此条件下产率最高达到83％。该方法温和简单，安全环保，是一种合成的好方法。
이신타기갑완구유특별적생리활성，시일충흔호적항암약물。고체산안기광산주최화제，신타여철、동반응합성료일계렬이신타기완경。대용제，온도，반응시간등공예조건진행료탐토，우화조건위：수주용제，온도30～40℃，반응시간3h，차조건하산솔최고체도83％。해방법온화간단，안전배보，시일충합성적호방법。
Bis（ indol -3 -yl）methanes were good anticancer medicine for their specil biological activity. A solid acid sulfamic acid catalyzed the reaction of indole with aldehyde and ketone to afford bis （indol -3 -yl）methanes. The solvent, temperature, time and so on process conditions were explored, and the optimized conditions were water as sol- vent, temperature range 30 -40 ℃, and 3 h. The best yield was 83% , under the optimized conditions. This synthetic method was a gentle, simple, green and safe good technique.