机电信息
機電信息
궤전신식
MECHANICAL AND ELECTRICAL INFORMATION
2012年
17期
6-9
,共4页
侯有明%吴仕清%耿熠%丁楚良%赖维华
侯有明%吳仕清%耿熠%丁楚良%賴維華
후유명%오사청%경습%정초량%뢰유화
重压法%制粒%工艺%设备
重壓法%製粒%工藝%設備
중압법%제립%공예%설비
Heavy--press%granulation%technology%device
应用重压法干法制粒工艺和设备对多潘立酮分散片、乙酰螺旋霉素片、盐酸氟桂利嗪胶囊、右旋布洛芬片和女金胶囊进行了制粒，比较了制剂重量差异、含量及溶出度，并对现行制粒工艺进行生产经济性分析。结果：各品种重压法干法制粒成品重量差异、含量及溶出度符合要求，生产成本较湿法制粒降低60％以上。结论：重压法干法制粒工艺在固体制剂成型处方进行适当调整的前提下对湿法制粒工艺具有质量和经济上的替代性。
應用重壓法榦法製粒工藝和設備對多潘立酮分散片、乙酰螺鏇黴素片、鹽痠氟桂利嗪膠囊、右鏇佈洛芬片和女金膠囊進行瞭製粒，比較瞭製劑重量差異、含量及溶齣度，併對現行製粒工藝進行生產經濟性分析。結果：各品種重壓法榦法製粒成品重量差異、含量及溶齣度符閤要求，生產成本較濕法製粒降低60％以上。結論：重壓法榦法製粒工藝在固體製劑成型處方進行適噹調整的前提下對濕法製粒工藝具有質量和經濟上的替代性。
응용중압법간법제립공예화설비대다반립동분산편、을선라선매소편、염산불계리진효낭、우선포락분편화녀금효낭진행료제립，비교료제제중량차이、함량급용출도，병대현행제립공예진행생산경제성분석。결과：각품충중압법간법제립성품중량차이、함량급용출도부합요구，생산성본교습법제립강저60％이상。결론：중압법간법제립공예재고체제제성형처방진행괄당조정적전제하대습법제립공예구유질량화경제상적체대성。
After prepare some products by Heavy-press granulation,such as Domperidone Dispersible Tablet,Acetylspiramycin Tablets,Flunarizine Hydrochloride Capsules,lbuprofen Tablets and Nvjin Capsules;and the weight variation,content,dissolution, and the process economic analysis were given.Results：The weight variation,content and dissolution of the products meet the requirements;and production costs reduced by 60% over Wet-granulation.Conclusion：Under the premise of prescription adjustments,Heavy-press granulation technology has the quality and economic alternative in comparison with Wet-granulation process.
