国际医药卫生导报
國際醫藥衛生導報
국제의약위생도보
INTERNATIONAL MEDICINE & HEALTH GUIDANCE NEWS
2014年
13期
1972-1975
,共4页
糖化血红蛋白%尿微量白蛋白/肌酐比值%糖尿病肾病%临床诊断
糖化血紅蛋白%尿微量白蛋白/肌酐比值%糖尿病腎病%臨床診斷
당화혈홍단백%뇨미량백단백/기항비치%당뇨병신병%림상진단
Glycosylated haemoglobin%Urinary albumin to creatinine ratio%Diabetic nephropathy%Diagnosis
目的 探讨糖化血红蛋白(HbA1c)和尿微量白蛋白/肌酐比值(UACR)在糖尿病肾病诊断中的临床价值.方法 检测67例糖尿病肾病、87例2型糖尿病非肾病以及120例健康对照组血糖化血红蛋白以及尿微量白蛋白、尿肌酐值.统计分析不同病程患者的糖化血红蛋白以及尿微量白蛋白/尿肌酐比值结果.通过诊断试验评估分析检测HbA1c和UACR对糖尿病肾病诊断的临床价值.结果 HbA1c和UACR水平和糖尿病肾病病程有很密切关系,随病程的延长呈逐步上升趋势.糖尿病肾病组UACR水平与正常组以及2型糖尿病非肾病组相比均具有统计学差异(P＜0.01).诊断试验评估发现单独检测UACR比单独检测HbA1c对糖尿病肾病的诊断能力强(HbA1c阳性似然比和阴性似然比分别为1.17、0.82;UACR阳性似然比和阴性似然比分别为6.12、0.04).结论 HbA1c和UACR联合检测可以提高糖尿病肾病的诊断价值,使糖尿病肾病的早期诊断更加稳定可靠.
目的 探討糖化血紅蛋白(HbA1c)和尿微量白蛋白/肌酐比值(UACR)在糖尿病腎病診斷中的臨床價值.方法 檢測67例糖尿病腎病、87例2型糖尿病非腎病以及120例健康對照組血糖化血紅蛋白以及尿微量白蛋白、尿肌酐值.統計分析不同病程患者的糖化血紅蛋白以及尿微量白蛋白/尿肌酐比值結果.通過診斷試驗評估分析檢測HbA1c和UACR對糖尿病腎病診斷的臨床價值.結果 HbA1c和UACR水平和糖尿病腎病病程有很密切關繫,隨病程的延長呈逐步上升趨勢.糖尿病腎病組UACR水平與正常組以及2型糖尿病非腎病組相比均具有統計學差異(P＜0.01).診斷試驗評估髮現單獨檢測UACR比單獨檢測HbA1c對糖尿病腎病的診斷能力彊(HbA1c暘性似然比和陰性似然比分彆為1.17、0.82;UACR暘性似然比和陰性似然比分彆為6.12、0.04).結論 HbA1c和UACR聯閤檢測可以提高糖尿病腎病的診斷價值,使糖尿病腎病的早期診斷更加穩定可靠.
목적 탐토당화혈홍단백(HbA1c)화뇨미량백단백/기항비치(UACR)재당뇨병신병진단중적림상개치.방법 검측67례당뇨병신병、87례2형당뇨병비신병이급120례건강대조조혈당화혈홍단백이급뇨미량백단백、뇨기항치.통계분석불동병정환자적당화혈홍단백이급뇨미량백단백/뇨기항비치결과.통과진단시험평고분석검측HbA1c화UACR대당뇨병신병진단적림상개치.결과 HbA1c화UACR수평화당뇨병신병병정유흔밀절관계,수병정적연장정축보상승추세.당뇨병신병조UACR수평여정상조이급2형당뇨병비신병조상비균구유통계학차이(P＜0.01).진단시험평고발현단독검측UACR비단독검측HbA1c대당뇨병신병적진단능력강(HbA1c양성사연비화음성사연비분별위1.17、0.82;UACR양성사연비화음성사연비분별위6.12、0.04).결론 HbA1c화UACR연합검측가이제고당뇨병신병적진단개치,사당뇨병신병적조기진단경가은정가고.
Objective To investigate the value of the glycosylated haemoglobin (HbA1c) and urinary albumin to creatinine ratio (UACR) in the diagnosis of diabetic kidney disease.Methods HbA1c,microalbuminuria and creatinine were detected in 67 diabetic kidney patients,87 type 2 diabetic non-nephropathy cases and 120 health subjects.The value of HbA1c and UACR in different course of diabetic kidney and type 2 diabetic non-nephropathy were analyzed.Results The HbA1c and UACR had a rising trend according to the development of diabetic kidney.UACR level of diabetic nephropathy group showed statistical significant difference compared with those of normal group and type 2 diabetic non-nephropathy group (P ＜ 0.01).Single diagnosis of UACR had higher diagnosis ability than those of HbA1c during the diagnostic test (positive likelihood ratio and negative likelihood ratio in HbA1c were 1.17 and 0.82; positive likelihood ratio and negative likelihood ratio in UACR were 6.12 and 0.04).Conclusion Combined detection of HbAlc and UACR can improve the diagnosis of diabetic kidney,making the diagnostic results more stabile and reliable.
