中华老年医学杂志
中華老年醫學雜誌
중화노년의학잡지
Chinese Journal of Geriatrics
2013年
4期
353-356
,共4页
任肖玉%周明珠%干静%万赢%陆丽霞%吴佳英%何海燕%魏雅荣%刘振国
任肖玉%週明珠%榦靜%萬贏%陸麗霞%吳佳英%何海燕%魏雅榮%劉振國
임초옥%주명주%간정%만영%륙려하%오가영%하해연%위아영%류진국
帕金森病%生活质量%抑郁%前瞻性研究
帕金森病%生活質量%抑鬱%前瞻性研究
파금삼병%생활질량%억욱%전첨성연구
Parkinson disease%Quality of life%Depression%Prospective studies
目的 探讨帕金森病(Parkinson's disease,PD)患者生活质量变化及其预测因素. 方法 收集2007年4-12月我院门诊就诊及住院的PD患者,最终符合条件患者81例.入组时收集患者病史及进行神经系统检查,并应用统一帕金森病评分量表(UPDRS)、Hoehn-Yahr(H-Y)分期量表、汉密尔顿焦虑量表(HAMA)、汉密尔顿抑郁量表(HRSD)、简易精神状态量表(MMSE)、帕金森睡眠量表(PDSS)、Epworth嗜睡量表(ESS)评估患者的临床症状,运用帕金森病生活质量问卷(PDQ-39)评估患者的生活质量.在收集患者资料的基础上对患者进行随访,随访3年后对患者再次进行评估. 结果 随访末患者UPDRS总分(UPDRS-T)、UPDRS运动评分(UPDRSⅢ)、HY分级、PDQ-39评分分别为(52.65±18.03)分、(29.91±11.58)分、(2.51±0.80)级、(45.10±20.63)分,较基线(31.23±15.66)分、(20.59±10.73)分、(2.15±0.81)级、(26.62±18.39)分均增加(t=16.79、5.94、3.44、21.67,均P＜0.05),PD患者病情进展,患者生活质量下降.PDQ-39增加的分数与衡量患者病情的UPDRS和H-Y增长值相关(r=0.255、0.280,均P＜0.05)；多元回归分析显示,影响PD患者生活质量的主要因素为抑郁(OR=1.223,P=0.005). 结论 帕金森病患者生活质量随病程不断恶化,高抑郁评分是生活质量恶化的重要预测因素,应早期发现并及时干预.
目的 探討帕金森病(Parkinson's disease,PD)患者生活質量變化及其預測因素. 方法 收集2007年4-12月我院門診就診及住院的PD患者,最終符閤條件患者81例.入組時收集患者病史及進行神經繫統檢查,併應用統一帕金森病評分量錶(UPDRS)、Hoehn-Yahr(H-Y)分期量錶、漢密爾頓焦慮量錶(HAMA)、漢密爾頓抑鬱量錶(HRSD)、簡易精神狀態量錶(MMSE)、帕金森睡眠量錶(PDSS)、Epworth嗜睡量錶(ESS)評估患者的臨床癥狀,運用帕金森病生活質量問捲(PDQ-39)評估患者的生活質量.在收集患者資料的基礎上對患者進行隨訪,隨訪3年後對患者再次進行評估. 結果 隨訪末患者UPDRS總分(UPDRS-T)、UPDRS運動評分(UPDRSⅢ)、HY分級、PDQ-39評分分彆為(52.65±18.03)分、(29.91±11.58)分、(2.51±0.80)級、(45.10±20.63)分,較基線(31.23±15.66)分、(20.59±10.73)分、(2.15±0.81)級、(26.62±18.39)分均增加(t=16.79、5.94、3.44、21.67,均P＜0.05),PD患者病情進展,患者生活質量下降.PDQ-39增加的分數與衡量患者病情的UPDRS和H-Y增長值相關(r=0.255、0.280,均P＜0.05)；多元迴歸分析顯示,影響PD患者生活質量的主要因素為抑鬱(OR=1.223,P=0.005). 結論 帕金森病患者生活質量隨病程不斷噁化,高抑鬱評分是生活質量噁化的重要預測因素,應早期髮現併及時榦預.
목적 탐토파금삼병(Parkinson's disease,PD)환자생활질량변화급기예측인소. 방법 수집2007년4-12월아원문진취진급주원적PD환자,최종부합조건환자81례.입조시수집환자병사급진행신경계통검사,병응용통일파금삼병평분량표(UPDRS)、Hoehn-Yahr(H-Y)분기량표、한밀이돈초필량표(HAMA)、한밀이돈억욱량표(HRSD)、간역정신상태량표(MMSE)、파금삼수면량표(PDSS)、Epworth기수량표(ESS)평고환자적림상증상,운용파금삼병생활질량문권(PDQ-39)평고환자적생활질량.재수집환자자료적기출상대환자진행수방,수방3년후대환자재차진행평고. 결과 수방말환자UPDRS총분(UPDRS-T)、UPDRS운동평분(UPDRSⅢ)、HY분급、PDQ-39평분분별위(52.65±18.03)분、(29.91±11.58)분、(2.51±0.80)급、(45.10±20.63)분,교기선(31.23±15.66)분、(20.59±10.73)분、(2.15±0.81)급、(26.62±18.39)분균증가(t=16.79、5.94、3.44、21.67,균P＜0.05),PD환자병정진전,환자생활질량하강.PDQ-39증가적분수여형량환자병정적UPDRS화H-Y증장치상관(r=0.255、0.280,균P＜0.05)；다원회귀분석현시,영향PD환자생활질량적주요인소위억욱(OR=1.223,P=0.005). 결론 파금삼병환자생활질량수병정불단악화,고억욱평분시생활질량악화적중요예측인소,응조기발현병급시간예.
Objective To investigate the changes of life quality in Parkinson's disease patients and the predictive factors.Methods A total of 81 patients in our hospital from April to December 2007 were involved.Medical history was collected and the nervous system was examined.The clinical characteristic was assessed by unified Parkinson's disease rating scale(UPDRS),Hoehn-Yahr stage,Hamilton anxiety scale(HAMA),Hamilton depression scale(HRSD),mini mental state examination (MMSE).The quality of life in Parkinson's disease was assessed by using PDQ-39 questionnaire.After 3 years follow-up,thc patients were assessed by these questionnaires again.Results The scores of UPDRS T,UPDRS Ⅲ,Hoehn-Yahr stage,PDQ-39 at 3-year follow-up were increased remarbably compared with the baseline [(52.65± 18.03),(29.91± 11.58),(2.51 ±0.80),(45.10±20.63) vs.(31.23±15.66),(20.59±10.73),(2.15±0.81),(26.62±18.39),respectiely,t=16.79,5.94,3.44,21.67,all P＜0.05].With the deterioration in Parkinson's disease,the quality of life of the patients were decreased significantly.There was a positive relationship of △PDQ-39 with △UPDRS and △H-Y (r=0.255,0.280,both P＜0.05).Multiple regression analysis showed that the main factor affecting the quality of life in the Parkinson's disease was depression (OR=1.216,P=0.005).Conclusions With the deterioration in Parkinson's disease,the quality of life is decreased significantly.Depression is the important predictor of quality of life in Parkinson's disease.
