CAJ | 학술논문

近年来研究发现维生素D不仅是调节钙磷代谢、保持骨骼健康的关键因子,还具有免疫调节、抗增殖、诱导分化和促进凋亡的作用.危重患者是维生素D缺乏的高危人群,维生素D缺乏与疾病严重程度和不良后果相关.维生素D的生物多效性决定了其在遏制危重病发生发展中可能扮演着重要角色,有望成为危重患者的辅助治疗手段.
근년래연구발현유생소D불부시조절개린대사、보지골격건강적관건인자,환구유면역조절、항증식、유도분화화촉진조망적작용.위중환자시유생소D결핍적고위인군,유생소D결핍여질병엄중정도화불량후과상관.유생소D적생물다효성결정료기재알제위중병발생발전중가능분연착중요각색,유망성위위중환자적보조치료수단.
[Summary] There is growing awareness of the importance of vitamin D beyond maintenance of musculoskeletal health.Vitamin D has been shown to have extensive biological functions,including modulating immune function,inhibiting cellular proliferation,inducing differentiation,promoting apoptosis.Vitamin D deficiency is highly prevalent in critically ill patients,and it may impact the severity of illness and contribute to lessthan-optimal outcomes.Vitamin D plays an important role in preventing the development of critical illness based on its pleiotropic actions,thus holding a profound prospective with respect to an adjunctive therapy in critically ill patients.