CAJ | 학술논문

目的观察丁苯酞软胶囊联合阿司匹林预防脑梗死复发的临床疗效.方法选取我院2009年1月至2010年1月期间收治的脑梗死病例76例,随机将其分为治疗组(使用丁苯酞软胶囊联合阿司匹林预防治疗)和对照组(单独使用阿司匹林预防治疗)各38例,两组均服用阿司匹林100 mg,1次/日,治疗组在阿司匹林治疗基础上联合应用丁苯酞软胶囊0.2 g,3次/日,治疗前及治疗1年后复查血小板聚集率血液流变学及血液流变学.随访1年,观察两组的治疗效果,并分析比较.结果治疗组中复发5例,复发率13.16％,对照组中复发8例,复发率21.05％,和对照组相比,治疗组治疗后血小板聚集率进一步降低,血液流变学改善,两组治疗效果差异有统计学意义(P＜0.05),治疗组比对照组效果好.结论采用丁苯酞软胶囊联合阿司匹林预防脑梗死复发的效果比单用阿司匹林的效果明显,治疗后血小板聚集率下降及血液流变学改善,随访患者复发少,预防效果好,值得临床推广使用.
목적 관찰정분태연효낭연합아사필림예방뇌경사복발적림상료효.방법 선취아원2009년1월지2010년1월기간수치적뇌경사병례76례,수궤장기분위치료조(사용정분태연효낭연합아사필림예방치료)화대조조(단독사용아사필림예방치료)각38례,량조균복용아사필림100 mg,1차/일,치료조재아사필림치료기출상연합응용정분태연효낭0.2 g,3차/일,치료전급치료1년후복사혈소판취집솔혈액류변학급혈액류변학.수방1년,관찰량조적치료효과,병분석비교.결과 치료조중복발5례,복발솔13.16％,대조조중복발8례,복발솔21.05％,화대조조상비,치료조치료후혈소판취집솔진일보강저,혈액류변학개선,량조치료효과차이유통계학의의(P＜0.05),치료조비대조조효과호.결론 채용정분태연효낭연합아사필림예방뇌경사복발적효과비단용아사필림적효과명현,치료후혈소판취집솔하강급혈액류변학개선,수방환자복발소,예방효과호,치득림상추엄사용.
Objective To evaluate the clinical efficacy and safety of butylphthalide soft capsules combined with aspirin for the prevention of ischemic stroke.Methods 76 patients admitted to our hospital from January 2009 to January 2010 were randomly divided to two groups,38 for Each group.Patients in both groups took aspirin 100 mg,once per day.Besides this,butylphthalide soft capsules were used in the treatment group,0.2 g,3 times per day.Before and after the one year's treatment,hemorheology were used to assess the therapeutic effect.The platelet aggregation rate (PAR) were analysed in two groups after treatment.Results 5 (13.16％) recurred in treatment group and 8 (21.05％) in the control group.and the difference was significant.PAR was lower and hemorheology was better in the treatment group than in the control group.There was statistical difference in treatment effect between these 2 groups.Conclusions Butylphthalide soft capsules combined with aspirin for the prevention of stroke has better effect than aspirin only.After this treatment,PAR will be lower and hemorheology better,fewer patients recur.It has good prevention effect and is worth popularizing clinically.