中国综合临床
中國綜閤臨床
중국종합림상
CLINICAL MEDICINE OF CHINA
2013年
6期
648-651
,共4页
汤建燕%颜静%顾奇云%邬叶锋%熊强%赵登秋
湯建燕%顏靜%顧奇雲%鄔葉鋒%熊彊%趙登鞦
탕건연%안정%고기운%오협봉%웅강%조등추
胆囊结石%血脂%围绝经期
膽囊結石%血脂%圍絕經期
담낭결석%혈지%위절경기
Gallstone stone%Serum lipids level%Peri-menopausal period
目的 探讨女性围绝经期的血脂水平与胆囊结石形成的关系,为预防胆囊结石提供理论依据.方法 选取上海市金山区中心医院肝胆外科女性腹腔镜胆囊切除术患者72例作为结石组,并选择同期该院体检中心体检的健康女性52名作为对照组,各组按年龄分别划分为20～29岁、30～ 39岁、40～49岁、50～ 59岁、60～69岁的5个不同年龄段以及低龄期(30 ～40岁)、围绝经期(45～55岁)的两个不同年龄期.测定其胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)浓度,以及计算体质量指数.比较各组间及组内的差异.结果 结石组围绝经期TC[(4.58 ±0.27) mmol/L]、HDL-C[(1.17 ±0.11) mmol/L]、LDL-C[(2.71 ±0.30) mmol/L]低于对照组围绝经期[(5.15±0.26)mmol/L、(1.40±0.08) mmol/L、(3.15±0.26) mmol/L],两组比较差异有统计学意义(t值分别为3.112、3.351、2.437,P＜0.01、P＜0.01、P＜0.05).结石组低龄期TC、TG、HDL-C、LDL-C、体质量指数与对照组低龄期比较差异均无统计学意义(P均＞0.05).结石组围绝经期HDL-C[(1.17 ±0.11) mmol/L]低于本组低龄期[(1.33±0.07) mmol/L],两者比较差异有统计学意义(t=2.455,P＜0.05).对照组围绝经期TC[(5.15 ±0.26) mmol/L]、TG[(1.88±0.39) mmol/L]、LDL-C [(3.15 ±0.26) mmol/L]、体质量指数[(24.75±0.99) kg/m2]高于本组低龄期[(4.47 ±0.34) mmol/L、(1.10 ±0.24) mmol/L、(2.71 ±0.31) mmol/L、(21.73 ±].11) kg/m2],两者比较差异均有统计学意义(t值分别为3.175、3.066、2.261、4.217,P＜0.01、P＜0.01、P＜0.05、P＜0.01).结论 对于围绝经期(45～55岁)女性,血清TC、HDL-C、LDL-C水平降低可能是胆固醇结石形成的相关因素,其中以HDL-C 降低关系密切,调节血脂可成为围绝经期女性预防胆囊结石的措施之一.
目的 探討女性圍絕經期的血脂水平與膽囊結石形成的關繫,為預防膽囊結石提供理論依據.方法 選取上海市金山區中心醫院肝膽外科女性腹腔鏡膽囊切除術患者72例作為結石組,併選擇同期該院體檢中心體檢的健康女性52名作為對照組,各組按年齡分彆劃分為20～29歲、30～ 39歲、40～49歲、50～ 59歲、60～69歲的5箇不同年齡段以及低齡期(30 ～40歲)、圍絕經期(45～55歲)的兩箇不同年齡期.測定其膽固醇(TC)、甘油三酯(TG)、低密度脂蛋白膽固醇(LDL-C)、高密度脂蛋白膽固醇(HDL-C)濃度,以及計算體質量指數.比較各組間及組內的差異.結果 結石組圍絕經期TC[(4.58 ±0.27) mmol/L]、HDL-C[(1.17 ±0.11) mmol/L]、LDL-C[(2.71 ±0.30) mmol/L]低于對照組圍絕經期[(5.15±0.26)mmol/L、(1.40±0.08) mmol/L、(3.15±0.26) mmol/L],兩組比較差異有統計學意義(t值分彆為3.112、3.351、2.437,P＜0.01、P＜0.01、P＜0.05).結石組低齡期TC、TG、HDL-C、LDL-C、體質量指數與對照組低齡期比較差異均無統計學意義(P均＞0.05).結石組圍絕經期HDL-C[(1.17 ±0.11) mmol/L]低于本組低齡期[(1.33±0.07) mmol/L],兩者比較差異有統計學意義(t=2.455,P＜0.05).對照組圍絕經期TC[(5.15 ±0.26) mmol/L]、TG[(1.88±0.39) mmol/L]、LDL-C [(3.15 ±0.26) mmol/L]、體質量指數[(24.75±0.99) kg/m2]高于本組低齡期[(4.47 ±0.34) mmol/L、(1.10 ±0.24) mmol/L、(2.71 ±0.31) mmol/L、(21.73 ±].11) kg/m2],兩者比較差異均有統計學意義(t值分彆為3.175、3.066、2.261、4.217,P＜0.01、P＜0.01、P＜0.05、P＜0.01).結論 對于圍絕經期(45～55歲)女性,血清TC、HDL-C、LDL-C水平降低可能是膽固醇結石形成的相關因素,其中以HDL-C 降低關繫密切,調節血脂可成為圍絕經期女性預防膽囊結石的措施之一.
목적 탐토녀성위절경기적혈지수평여담낭결석형성적관계,위예방담낭결석제공이론의거.방법 선취상해시금산구중심의원간담외과녀성복강경담낭절제술환자72례작위결석조,병선택동기해원체검중심체검적건강녀성52명작위대조조,각조안년령분별화분위20～29세、30～ 39세、40～49세、50～ 59세、60～69세적5개불동년령단이급저령기(30 ～40세)、위절경기(45～55세)적량개불동년령기.측정기담고순(TC)、감유삼지(TG)、저밀도지단백담고순(LDL-C)、고밀도지단백담고순(HDL-C)농도,이급계산체질량지수.비교각조간급조내적차이.결과 결석조위절경기TC[(4.58 ±0.27) mmol/L]、HDL-C[(1.17 ±0.11) mmol/L]、LDL-C[(2.71 ±0.30) mmol/L]저우대조조위절경기[(5.15±0.26)mmol/L、(1.40±0.08) mmol/L、(3.15±0.26) mmol/L],량조비교차이유통계학의의(t치분별위3.112、3.351、2.437,P＜0.01、P＜0.01、P＜0.05).결석조저령기TC、TG、HDL-C、LDL-C、체질량지수여대조조저령기비교차이균무통계학의의(P균＞0.05).결석조위절경기HDL-C[(1.17 ±0.11) mmol/L]저우본조저령기[(1.33±0.07) mmol/L],량자비교차이유통계학의의(t=2.455,P＜0.05).대조조위절경기TC[(5.15 ±0.26) mmol/L]、TG[(1.88±0.39) mmol/L]、LDL-C [(3.15 ±0.26) mmol/L]、체질량지수[(24.75±0.99) kg/m2]고우본조저령기[(4.47 ±0.34) mmol/L、(1.10 ±0.24) mmol/L、(2.71 ±0.31) mmol/L、(21.73 ±].11) kg/m2],량자비교차이균유통계학의의(t치분별위3.175、3.066、2.261、4.217,P＜0.01、P＜0.01、P＜0.05、P＜0.01).결론 대우위절경기(45～55세)녀성,혈청TC、HDL-C、LDL-C수평강저가능시담고순결석형성적상관인소,기중이HDL-C 강저관계밀절,조절혈지가성위위절경기녀성예방담낭결석적조시지일.
Objective To investigate the relationship between peri-menopausal women blood lipid level and the gallstone disease in order to provide theoretical basis for the prevention of gallbladder stone.Methods Seventy-two patients with gallbladder calculus from Department of Hepatobiliary Surgery Jinshan District Central Hospital of Shanghai and 52 healthy women coming for physical examination as the control group.Participants were divided into five age groups (20-29,30-39,40-49,50-59 and 60-69 years old) and two age stages (young period (30-40 years old) and peri-menopausal period (45-55 years old)),total cholesterol (TC),triglyceride (TG),high density lipoprotein (HDL-C),low-density lipoproteins (LDL-C) and Body Mass Index (BMI) were determined and compared between the stone group and the control group at different age stages.Results In comparison of the menopausal transition period,the stone group had significantly lower blood TC,HDL-C and LDL-C levels than the control group (TC:(4.58 ± 0.27) mmol/L vs.(5.15 ± 0.26) mmol/L,t=3.112,P ＜0.01 ;HDL-C:(1.17 ±0.11) mmol/L vs.(1.40 ±0.08) mmol/L,t =3.351,P ＜0.01 ;LDL-C:(2.71 ± 0.30) mmol/L vs.(3.15 ± 0.26) mmol/L,t =2.437,P ＜ 0.05).For the young period,there were no significant difference on blood lipid level and BMI was observed between the stone group and the control group (P ＞ 0.05).The fat HDL-C level in blood was significantly lower in the stone group in the menopausal transition period than in the young period ((1.17 ± 0.11) mmol/L vs.(1.33 ± 0.07) mmol/L,t =2.455,P ＜ 0.05).The control group had significantly higher peri-menopausal TC,TG,LDL-C levels in blood and BMI than those in the control group young period (P ＜ 0.05) ; And HDL-C level,no significant difference (TC:(5.15 ± 0.26)mmol/L vs.(4.47 ± 0.34) mmol/L,t =3.175,P ＜ 0.01 ; TG:(1.88 ± 0.39) mmol/L vs.(1.10 ± 0.24)mmol/L,t=3.066,P＜0.01;LDL-C:(3.15 ±0.26) mmol/L vs.(2.71 ±0.31) mmol/L,t =2.261,P＜0.05;BMI:(24.75±0.99) kg/m2vs.(21.73±1.11) kg/m2,t=4.217,P＜0.01).Conclnsion For perimenopausal (45-55 years old) females,decline of serum TC,HDL-C and LDL-C levels may be related to the formation of cholesterol stone.Lower HDL-C level is closely associated with formation of cholesterol stone,indicating that it may be one of the measures to prevent gallbladder stone by adjusting blood fat in perimenopausal women.
