CAJ | 학술논문

根据农业部《兽药试验技术规范汇编》观察了仔猪痢清口服液对小白鼠的亚慢性毒性，试验组分设高、中、低3个剂量组，另设空白对照组，连续给药28 d后剖杀各组小鼠。统计学分析结果表明，各组间的体重变化和脏器系数比较无显著差异；各试验组的血常规检测指标、血液生化学检测指标的测定结果与空白对照组测定结果相比差异均不显著；组织病理学检查显示小鼠的主要内脏器官未见明显异常变化。试验结果表明仔猪痢清口服液按临床剂量使用无毒性反应，应用安全可靠。
근거농업부《수약시험기술규범회편》관찰료자저리청구복액대소백서적아만성독성，시험조분설고、중、저3개제량조，령설공백대조조，련속급약28 d후부살각조소서。통계학분석결과표명，각조간적체중변화화장기계수비교무현저차이；각시험조적혈상규검측지표、혈액생화학검측지표적측정결과여공백대조조측정결과상비차이균불현저；조직병이학검사현시소서적주요내장기관미견명현이상변화。시험결과표명자저리청구복액안림상제량사용무독성반응，응용안전가고。
To study the subchronic toxicity of the Zizhuliqing oral liquid, the test was conducted in accordance with the animal drug technological specification compile of Ministry of Agriculture. Experiment mouse were divide into 4 groups, the 3 experiment groups were given Zizhuliqing oral liquid by oral gavage for 28 days at dose levels of 0.01 mL/g·body, 0.02 mL/g·body, 0.04 mL/g·body weight per day. The control group was given saline. Results showed that the body weight, organ coefficient, the index of hematology and blood biochemistry were not signifi-cantly different from that in the control group (p>0.05). In addition, results of histopathology examination showed that no obvious abnormalities in the major organ of mice were found among experimental groups after administra-tion of the Zizhuliqing oral liquid. Therefore, our study suggested that the Zizhuliqing oral liquid had no subchronic toxicity and could be safely used for experimental animals.