心血管病防治知识（下半月）
心血管病防治知識（下半月）
심혈관병방치지식（하반월）
XINXUEGUANBING FANGZHI ZHISHI
2013年
12期
145-147
,共3页
电压门控性钾通道%肺动脉高压%增殖%凋亡%血管收缩
電壓門控性鉀通道%肺動脈高壓%增殖%凋亡%血管收縮
전압문공성갑통도%폐동맥고압%증식%조망%혈관수축
Voltage -gated potassium channel%Pulmonary hypertension%Proliferation%Apoptosis%Vasoconstriction
肺动脉高压是一种肺血流受限引起肺血管阻力和压力持续性增高，最终导致右心衰竭甚至死亡的综合征，病理生理学的改变主要为肺血管收缩、重塑及原位血栓的形成。近年研究表明，钾离子通道决定着肺动脉平滑肌细胞膜上的膜静息电位形成、调节血管紧张性及参与肺动脉平滑肌细胞的生长、增殖和凋亡。因此，钾通道调节血管收缩和调控肺动脉平滑肌细胞（Pulmonary artery smooth muscle cells, PASMCs）凋亡等方面发挥重要作用，具有抗肺动脉高压的作用，有望成为治疗肺动脉高压的新靶点[1]。
肺動脈高壓是一種肺血流受限引起肺血管阻力和壓力持續性增高，最終導緻右心衰竭甚至死亡的綜閤徵，病理生理學的改變主要為肺血管收縮、重塑及原位血栓的形成。近年研究錶明，鉀離子通道決定著肺動脈平滑肌細胞膜上的膜靜息電位形成、調節血管緊張性及參與肺動脈平滑肌細胞的生長、增殖和凋亡。因此，鉀通道調節血管收縮和調控肺動脈平滑肌細胞（Pulmonary artery smooth muscle cells, PASMCs）凋亡等方麵髮揮重要作用，具有抗肺動脈高壓的作用，有望成為治療肺動脈高壓的新靶點[1]。
폐동맥고압시일충폐혈류수한인기폐혈관조력화압력지속성증고，최종도치우심쇠갈심지사망적종합정，병리생이학적개변주요위폐혈관수축、중소급원위혈전적형성。근년연구표명，갑리자통도결정착폐동맥평활기세포막상적막정식전위형성、조절혈관긴장성급삼여폐동맥평활기세포적생장、증식화조망。인차，갑통도조절혈관수축화조공폐동맥평활기세포（Pulmonary artery smooth muscle cells, PASMCs）조망등방면발휘중요작용，구유항폐동맥고압적작용，유망성위치료폐동맥고압적신파점[1]。
Pulmonary hypertension is a syndrome where pulmonary vascular resistance and pressure increase continuously due to limited pulmonary blood flow, eventually leading to right heart failure and even death. Pathophysiological changes mainly include pulmonary vasoconstriction, remodeling, and in situ thrombosis. In recent years, studies have shown that potassium channels determine the resting potential of pulmonary artery smooth muscle cells (PASMCs), regulate vascular tone, and are involved in the growth, proliferation, and apoptosis of PASMCs. Opening of potassium channels can inhibit vasoconstriction and induce apoptosis of PASMCs, thus reversing pulmonary hypertension. Therefore, potassium channel is expected to become a new target for the treatment of pulmonary hypertension.
