CAJ | 학술논문

胰岛素是通过胰岛素信号的转导通路来发挥其调节血糖并且促进其代谢合成的，其中磷脂酰肌醇-3激酶（PI-3K）在胰岛素信号转导中起关键性作用，而胰岛素信号转导通路障碍所引起的胰岛素抵抗在Ⅱ型糖尿病治疗中有着至关重要的作用．从胰岛素抵抗的发病机制、影响PI-3K的因素等几个方面综述了PI-3K在Ⅱ型糖尿病发病机制中的作用．
이도소시통과이도소신호적전도통로래발휘기조절혈당병차촉진기대사합성적，기중린지선기순-3격매（PI-3K）재이도소신호전도중기관건성작용，이이도소신호전도통로장애소인기적이도소저항재Ⅱ형당뇨병치료중유착지관중요적작용．종이도소저항적발병궤제、영향PI-3K적인소등궤개방면종술료PI-3K재Ⅱ형당뇨병발병궤제중적작용．
Insulin regulates blood sugar and promotes the anabolic metabolism through the insulin signal transduction pathway in which phosphatidylinositol-3-kinase （PI-3K） plays a key role in the insulin signal transduction, and the insulin resistance resulting from the disorder of the insulin signal transduction pathway is very important in the treatment of type 2 diabetes mellitus. The important role of PI-3 K in the pathogenesis of type 2 diabetes mellitus is reviewed by discussing the pathogenesis of the insulin resistance, the factor affecting PI-3 K, etc.