CAJ | 학술논문

泛素-蛋白酶体系统是细胞内蛋白质降解的重要途径之一，它通过降解细胞内各通路的抑制因子和（或）激活因子发挥上调和下调作用，是维持细胞内许多生理功能的重要系统。近年来，有文献报道泛素一蛋白酶体系统由于参与抑制疼痛的细胞因子和蛋白质降解，从而成为神经性疼痛的重要发病因素。实验已经证实蛋白酶体抑制剂能够抑制神经性疼痛和痛觉过敏，从而进一步肯定了泛素-蛋白酶体系统在神经性疼痛发生机制中的作用。
범소-단백매체계통시세포내단백질강해적중요도경지일，타통과강해세포내각통로적억제인자화（혹）격활인자발휘상조화하조작용，시유지세포내허다생리공능적중요계통。근년래，유문헌보도범소일단백매체계통유우삼여억제동통적세포인자화단백질강해，종이성위신경성동통적중요발병인소。실험이경증실단백매체억제제능구억제신경성동통화통각과민，종이진일보긍정료범소-단백매체계통재신경성동통발생궤제중적작용。
The ubiquitin-proteasome is one of the important pathways of the protein degradation in the cells, and it acts the role of upregulating or downregulating by degradating the inhibitor or activator, and it is one of the important systems in maintaining the physiological function in ceils. In recent years, some literatures report that the ubiquitin-proteasome is one of the important factors in the happening of the neuropathic pain because it degarades some of the cytokines and proteins which inhibit the pain. The ex- periments have proved that the proteasome inhibitor could inhibit the neuropathic pain and hyperalgesia, and confirm that ubiqui- tin-proteasome participate the neuropathic pain.