CAJ | 학술논문

目的通过建立兔硬脊膜外脓肿模型,对静脉注射抗生素与经硬脊膜外置管持续应用抗生素的疗效进行比较,探讨硬脊膜外脓肿的治疗效果.方法建立兔硬脊膜外置管模型,将16只兔随机分为3组:静脉应用抗生素组(A组)(n=6),硬脊膜外应用抗生素组(B组)(n=6),脓肿对照组(C组)(n=4).注入细菌建立硬脊膜外脓肿模型,记录体重、体温和血清C反应蛋白(CRP)值;取兔脊髓、背根神经节和神经根,行光镜、透射电镜(TEM)病理学检查.结果静脉实验组、硬脊膜外实验组兔用药前后血清CRP值有显著性差异(P＜0.05).结论静脉注射抗生素与经硬脊膜外置管持续注入抗生素,两组用药后均有效;硬脊膜外持续注入抗生素治疗方法可行且有效.
목적 통과건립토경척막외농종모형,대정맥주사항생소여경경척막외치관지속응용항생소적료효진행비교,탐토경척막외농종적치료효과.방법 건립토경척막외치관모형,장16지토수궤분위3조:정맥응용항생소조(A조)(n=6),경척막외응용항생소조(B조)(n=6),농종대조조(C조)(n=4).주입세균건립경척막외농종모형,기록체중、체온화혈청C반응단백(CRP)치;취토척수、배근신경절화신경근,행광경、투사전경(TEM)병이학검사.결과 정맥실험조、경척막외실험조토용약전후혈청CRP치유현저성차이(P＜0.05).결론 정맥주사항생소여경경척막외치관지속주입항생소,량조용약후균유효;경척막외지속주입항생소치료방법가행차유효.
Objective To investigate the effects of epidural antibioticson treatment of spinal epidural abscess(SEA)in rabbits in comparison with the use of intravenous antibiotics in veins.Methods Sixteen rabbits catheterized in epidurally,classified into 3 groups randomly:intvavenous antibiotics in vein(A group)(n=6),epidural antibiotics(B group)(n=6)and contral group(C group)(n=4).Developed an experimental model by injecting Staphylococcus aureus into the epidural space from the catheter to produce spinal epidund abscess in all groups.The food and drink,activity,body temperature,neurological dysfunction and C-reactive protein(CaD value of the rabitts were observed in the period.The pathological changes of SEA were studied in rabbits with light and transmission electron microscope.Results After administration of antibiotics,the CRP values were lower than before in both A and B groups(P＜0.05).The pathological changes were improved obviously after administration of antibiotics.Condusions The use of epidural antibiotics WaS as effective as inwavenous antibiotics in treatment of SEA.