CAJ | 학술논문

Ritter反应是构筑C—N键的重要手段之一，自1948年被发现以来广泛应用于脂肪族酰胺和杂环化合物（如内酰胺、嗯唑啉等）的合成。反应的催化剂也从最初的浓硫酸发展到多种质子酸（如甲磺酸，三氟甲磺酸等）和非质子酸（如SnCl4、BF3OEt2、杂多酸等）。本文综述了Ritter反应的进展及其在有机合成中的应用。
Ritter반응시구축C—N건적중요수단지일，자1948년피발현이래엄범응용우지방족선알화잡배화합물（여내선알、은서람등）적합성。반응적최화제야종최초적농류산발전도다충질자산（여갑광산，삼불갑광산등）화비질자산（여SnCl4、BF3OEt2、잡다산등）。본문종술료Ritter반응적진전급기재유궤합성중적응용。
Since the discovery of the Ritter reaction in 1948, it had been widely used for the preparation of acyclic amides as well as heterocycles, such as lactams, oxazolines, etc.. Based on concentrated sulfuric acid, several Bronsted acids ( e. g. methylsulfonic acid, triflic acid, etc. ) as well as Lewis acids ( e. g. SnCl4, BF30Et2, heteropolyacid, etc. ) have been developed to catalyze the reaction. It had been recognized as an important method to build C - N bond. Herein, the advances and main applications of the Ritter reaction were reviewed and summarized.