CAJ | 학술논문

目的：观察功能性食品＂糖脂康＂的安全性。方法：选用健康断乳SD大鼠为受试对象,随机分为4组。分别以1 875、3 750、7 500 mg/kg.BW剂量的糖脂康样品掺入基础饲料中喂养,对照组则给予基础饲料,连续30 d后检测相应指标。结果：试验期间及实验结束时,各剂量组动物体重增长、食物利用率、血常规、血生化指标及脏体系数均在正常范围内,与对照组比较,差异均无显著性（P〉0.05）;病理组织学检查表明各实验组大鼠肝、肾、胃、肠、脾、睾丸和卵巢等组织均未见有病理改变。结论：糖脂康对大鼠的生长、发育、代谢及脏器无急性不良影响,在本实验剂量范围内,无短期毒副作用。
목적：관찰공능성식품＂당지강＂적안전성。방법：선용건강단유SD대서위수시대상,수궤분위4조。분별이1 875、3 750、7 500 mg/kg.BW제량적당지강양품참입기출사료중위양,대조조칙급여기출사료,련속30 d후검측상응지표。결과：시험기간급실험결속시,각제량조동물체중증장、식물이용솔、혈상규、혈생화지표급장체계수균재정상범위내,여대조조비교,차이균무현저성（P〉0.05）;병리조직학검사표명각실험조대서간、신、위、장、비、고환화란소등조직균미견유병리개변。결론：당지강대대서적생장、발육、대사급장기무급성불량영향,재본실험제량범위내,무단기독부작용。
Objective： To observe the toxicological safety on functional food of Tangzhikang tablets. Methods： The SD ablactated rats were randomly divided into four groups. The control group was fed with basic diet. Three experimental groups were fed with basic diet mixed with Tangzhikang tablets with the dose of 1 875, 3 750 and 7 500 mg/kg on body weight for 30 days, respectively. The corresponding indexes of each group were measured. Results： During and at the end of the experiment, the body weight, food utilization rate, full blood count, blood biochemistry, and organ/body weigh ratios had no significant differences among the four groups. Furthermore, the histopathological examination showed that there were no significant changes in liver, kidney, stomach, intestines, spleen, testicle and ovary among the 4 groups. Conclusion： Tangzhikang tablet has no acute toxic effect and is a safe functional food on rats＂ growth, development, metabolism and viscera organs.