CAJ | 학술논문

慢性阻塞性肺疾病的发病与气道、肺实质和肺血管的慢性炎症、肺部的蛋白酶和抗蛋白酶失衡、氧化与抗氧化失衡等有关.其中氧化/抗氧化失衡是造成慢性阻塞性肺疾病慢性全身损伤的重要原因.N-乙酰半胱氨酸具有抗氧化及细胞保护作用,本文对近年来N-乙酰半胱氨酸治疗慢性阻塞性肺疾病的研究进展作一综述.
만성조새성폐질병적발병여기도、폐실질화폐혈관적만성염증、폐부적단백매화항단백매실형、양화여항양화실형등유관.기중양화/항양화실형시조성만성조새성폐질병만성전신손상적중요원인.N-을선반광안산구유항양화급세포보호작용,본문대근년래N-을선반광안산치료만성조새성폐질병적연구진전작일종술.
The pathogenesis of chronic obstructive pulmonary disease (COPD) is related to chronic inflammation of airway,lung parenchyma and lung vascular,imbalance of anti-protease and protease,as well as imbalance of oxidation and antioxidation in the lung.Oxidation and antioxidation imbalance is one of the most important reasons for systemic manifestations of COPD.N-acetylcysteine might provide antioxidation and cell protection.In this review article,we will summarize the research progress of Nacetylcysteine in the treatment of COPD.