CAJ | 학술논문

目的：评价注射用硝普钠在2种输液(氯化钠注射液、5%葡萄糖注射液)中的稳定性。方法：将注射用硝普钠按临床应用浓度配制成A、B、C、D四组溶液，考察不同环境条件下，不同放置时间硝普钠溶液的稳定性，包括溶液外观、不溶性微粒、pH、紫外-可见吸收光谱、硝普钠含量等。结果：在避光条件下，在20℃或35℃时，硝普钠与5%葡萄糖注射液或氯化钠注射液的配伍后26 h内是稳定的；在不用或用避光套避光且强光照射时，硝普钠溶液极不稳定。结论：氯化钠注射液和5%葡萄糖注射液均可作为注射用硝普钠的溶媒，且溶液在26 h内稳定。临床配制或使用硝普钠注射液时，要严格避光，才能保证用药安全有效。
목적：평개주사용초보납재2충수액(록화납주사액、5%포도당주사액)중적은정성。방법：장주사용초보납안림상응용농도배제성A、B、C、D사조용액，고찰불동배경조건하，불동방치시간초보납용액적은정성，포괄용액외관、불용성미립、pH、자외-가견흡수광보、초보납함량등。결과：재피광조건하，재20℃혹35℃시，초보납여5%포도당주사액혹록화납주사액적배오후26 h내시은정적；재불용혹용피광투피광차강광조사시，초보납용액겁불은정。결론：록화납주사액화5%포도당주사액균가작위주사용초보납적용매，차용액재26 h내은정。림상배제혹사용초보납주사액시，요엄격피광，재능보증용약안전유효。
Objective:To evaluate the compatible stability of sodium nitroprusside for injection ( SNP) in two kinds of solutions (5% glucose and sodium chloride injections) . Methods:A, B, C and D solution of SNP was respectively prepared according to the concentration of clinical use. The stability of SNP solution was studied in different environment with different storing time, and the as-sessment indices included the appearance, insoluble particles, pH value, ultraviolet-visible absorption spectrum and SNP content. Re-sults:The SNP solutions in 5% glucose and sodium chloride injections were stable in 26 hours in photophobic condition at 20℃ and 35℃. Under an incandescent lamp with or without lightproof, the solutions were very unstable. Conclusion:Both sodium chloride and 5% glucose injections can be used as the solvent for SNP with 26h stability. SNP injections prepared and used in clinics should be pre-served away from light to ensure the safety and effectiveness.