中国血液流变学杂志
中國血液流變學雜誌
중국혈액류변학잡지
CHINESE JOURNAL OF HEMORHEOLOGY
2013年
3期
541-543
,共3页
脊髓亚急性联合变性%神经损害%肌电图改变
脊髓亞急性聯閤變性%神經損害%肌電圖改變
척수아급성연합변성%신경손해%기전도개변
subacute combined degeneration of spinal cord%neural damage%electromyographic changes
目的：探讨脊髓亚急性联合变性（subacute combined degeneration of spinal cord，SCD）患者神经损害的影响因素及肌电图改变特点。方法收集42例确诊为SCD患者的临床资料并进行神经损害程度积分评定，分析血清VitB12、血红蛋白水平与神经损害程度的相关性，并总结其肌电图特点。结果 VitB12水平及血红蛋白浓度与神经损害程度积分均无显著相关（P＞0.05)。18例（42.9%）有运动神经传导速度减慢、远端潜伏期延长，其中8例伴有运动诱发电位波幅降低；24例（57.1%）有感觉神经传导速度减慢，10例伴有体感诱发电位波幅降低。结论 SCD神经损害程度与VitB12水平及贫血程度之间无线性相关；运动神经和感觉神经均可受损，但感觉神经更易累及；损害以神经脱髓鞘改变为主，可伴有轴索损伤。
目的：探討脊髓亞急性聯閤變性（subacute combined degeneration of spinal cord，SCD）患者神經損害的影響因素及肌電圖改變特點。方法收集42例確診為SCD患者的臨床資料併進行神經損害程度積分評定，分析血清VitB12、血紅蛋白水平與神經損害程度的相關性，併總結其肌電圖特點。結果 VitB12水平及血紅蛋白濃度與神經損害程度積分均無顯著相關（P＞0.05)。18例（42.9%）有運動神經傳導速度減慢、遠耑潛伏期延長，其中8例伴有運動誘髮電位波幅降低；24例（57.1%）有感覺神經傳導速度減慢，10例伴有體感誘髮電位波幅降低。結論 SCD神經損害程度與VitB12水平及貧血程度之間無線性相關；運動神經和感覺神經均可受損，但感覺神經更易纍及；損害以神經脫髓鞘改變為主，可伴有軸索損傷。
목적：탐토척수아급성연합변성（subacute combined degeneration of spinal cord，SCD）환자신경손해적영향인소급기전도개변특점。방법수집42례학진위SCD환자적림상자료병진행신경손해정도적분평정，분석혈청VitB12、혈홍단백수평여신경손해정도적상관성，병총결기기전도특점。결과 VitB12수평급혈홍단백농도여신경손해정도적분균무현저상관（P＞0.05)。18례（42.9%）유운동신경전도속도감만、원단잠복기연장，기중8례반유운동유발전위파폭강저；24례（57.1%）유감각신경전도속도감만，10례반유체감유발전위파폭강저。결론 SCD신경손해정도여VitB12수평급빈혈정도지간무선성상관；운동신경화감각신경균가수손，단감각신경경역루급；손해이신경탈수초개변위주，가반유축색손상。
Objective To investigate the influencing factors of neural damages on patients with subacute combined degeneration of spinal cord(SCD) and their electromyographic changes.Methods Clinical data of 42 SCD patients were collected and their degrees of neural damages were evaluated.Linear correlation analysis between Vit B12 level,hemoglobin concentration and degree of neural damage was performed, and their electromyographic changes were summarized.Results There was no significant relationship between Vit B12 level,hemoglobin concentration and neural damage score(P>0.05).18 patients(42.9%) had reduced conduction velocity of motor nerves and prolonged distal latency,8 of them had reduced amplitudes of motor evoked potential.24 patients(57.1%) had reduced conduction velocity of sensory nerves,10 of them had reduced amplitudes of somatosensory evoked potential.Conclusions There is no linear correlationship between Vit B12 level,anemia degree and neural damage degree in SCD patients.Both motor and sensory nerves could be damaged in SCD patients,but sensory nerves are more involved.The peripheral nervous damage is mainly neural demyelination,and axonal damage can also exist.
