中国血液流变学杂志
中國血液流變學雜誌
중국혈액류변학잡지
CHINESE JOURNAL OF HEMORHEOLOGY
2013年
3期
432-434
,共3页
放射性胸膜炎%氟伐他汀%大鼠%辐射防护剂
放射性胸膜炎%氟伐他汀%大鼠%輻射防護劑
방사성흉막염%불벌타정%대서%복사방호제
radiation-induced pleurisy%lfuvastatin%rats%radiation-protective agents
目的：观察氟伐他汀对大鼠放射性胸膜炎的防治作用。方法采用随机数字表法，将80只健康雌性SD大鼠分为对照组（n=8）、单纯放射组（n=36）、氟伐他汀组（n=36）。氟伐他汀组于照射前1周，给予20mg/（kg?d）氟伐他汀灌胃，直至活杀，其他组灌服等量生理盐水。单纯放射组和氟伐他汀组采用直线加速器全胸部照射，单次剂量20Gy。照射后对大鼠进行X线透视扫描，并在第15d、30d、60d以3.5%水合氯醛麻醉大鼠，剪开胸腔，对有胸水者进行病理和生化检查。结果单纯放射组放射性胸膜炎发生率为41.7%（15/36）。氟伐他汀组放射性胸膜炎发生率为19.4%（7/36）。两组之间的差异有统计学意义（χ2=4.19，P＜0.05）。经过对比发现氟伐他汀组病理学改变轻于同期的单纯放射组。结论放射性胸膜炎在放射性肺损伤的早期即可出现，氟伐他汀能有效防治大鼠放射性胸膜炎。
目的：觀察氟伐他汀對大鼠放射性胸膜炎的防治作用。方法採用隨機數字錶法，將80隻健康雌性SD大鼠分為對照組（n=8）、單純放射組（n=36）、氟伐他汀組（n=36）。氟伐他汀組于照射前1週，給予20mg/（kg?d）氟伐他汀灌胃，直至活殺，其他組灌服等量生理鹽水。單純放射組和氟伐他汀組採用直線加速器全胸部照射，單次劑量20Gy。照射後對大鼠進行X線透視掃描，併在第15d、30d、60d以3.5%水閤氯醛痳醉大鼠，剪開胸腔，對有胸水者進行病理和生化檢查。結果單純放射組放射性胸膜炎髮生率為41.7%（15/36）。氟伐他汀組放射性胸膜炎髮生率為19.4%（7/36）。兩組之間的差異有統計學意義（χ2=4.19，P＜0.05）。經過對比髮現氟伐他汀組病理學改變輕于同期的單純放射組。結論放射性胸膜炎在放射性肺損傷的早期即可齣現，氟伐他汀能有效防治大鼠放射性胸膜炎。
목적：관찰불벌타정대대서방사성흉막염적방치작용。방법채용수궤수자표법，장80지건강자성SD대서분위대조조（n=8）、단순방사조（n=36）、불벌타정조（n=36）。불벌타정조우조사전1주，급여20mg/（kg?d）불벌타정관위，직지활살，기타조관복등량생리염수。단순방사조화불벌타정조채용직선가속기전흉부조사，단차제량20Gy。조사후대대서진행X선투시소묘，병재제15d、30d、60d이3.5%수합록철마취대서，전개흉강，대유흉수자진행병리화생화검사。결과단순방사조방사성흉막염발생솔위41.7%（15/36）。불벌타정조방사성흉막염발생솔위19.4%（7/36）。량조지간적차이유통계학의의（χ2=4.19，P＜0.05）。경과대비발현불벌타정조병이학개변경우동기적단순방사조。결론방사성흉막염재방사성폐손상적조기즉가출현，불벌타정능유효방치대서방사성흉막염。
Objective To study the protective effect of fluvastatin on radiation-induced pleurisy model in rats.Methods 80 Healthy SD rats(180±20g) were randomly divided into 3 groups:normal control(n=8),radiation control(n=36) and radiation plus treatment with fluvastatin groups(n=36).The dose of thoracic radiation was 20 Gy by linear accelerator in 72 rats in the latter two groups after anesthesia.7 days prior to radiation,fluvastatin was given to the treatment group at a dose of 20 mg/kg per day by gastrogavage until the end of the experiment. The animals in the other groups were given same amount of saline by gastrogavage.The rats were scanned by X-ray after radiation.Chloral hydrate was injected intraperitoneally at a dose of 3.5%on 15, 30 and 60 days after radiation.After they were anesthetized,their thoraces were opened.If there was pleurorrhea,routine and biochemical examinations were carried out.Hematoxylin and eosin(H&E) stain were performed on the lung tissue slices to observe changes in microstructure.The data were analyzed by univariate of general linear model test of SPSS 13.0.Results Pleurisy induced by radiation was found in 22 of 72 rats.Incidence rate in radiation control group was 41.7%(15/36) and that in radiation plus treatment group was 19.4%(7/36).Compared to radiation control group,the pathologic change alleviated,and the rate of pleurisy in radiation plus treatment group decreased signiifcantly(P<0.05).Conclusion Pleurisy can occur in the early stage of radiation-induced lung injury.Fluvastatin has certain protective effect on radiation-induced pleurisy.
