CAJ | 학술논문

目的：探讨超声引导下冷循环微波刀在肝癌治疗中的近期疗效。方法对我院2008年3月至2010年4月收治的81例患者共112个病灶进行冷循环微波刀治疗，术前超声造影检查（CEUS）及微血管成像（MFI）并测量肿瘤大小，术后超声造影（CEUS）观察肿瘤灭活情况及肿瘤大小以及AFP变化情况，随访1、2、3年生存率。结果本组术前血清AFP（429±29.8）μg/L，术后1个月降低为（234±22.3）μg/L；病人术前病灶平均直径（50.2±11.3）mm，术后1个月病灶平均直径为（38.2±6.9）mm（P<0.05）；术后3个月病灶完全消失10例计12个病灶，无明显变化者8个病灶，余者均有不同程度缩小。术后1个月超声造影显示97个（86.6%）病灶呈无血流灌注、边界清晰的无增强状态，15个病灶部分边缘增强。结论超声引导下冷循环微波刀联合使用超声造影创治疗肝癌是一种十分有效的方法，作为微创治疗肝癌手段值得推广。
목적：탐토초성인도하랭순배미파도재간암치료중적근기료효。방법대아원2008년3월지2010년4월수치적81례환자공112개병조진행랭순배미파도치료，술전초성조영검사（CEUS）급미혈관성상（MFI）병측량종류대소，술후초성조영（CEUS）관찰종류멸활정황급종류대소이급AFP변화정황，수방1、2、3년생존솔。결과본조술전혈청AFP（429±29.8）μg/L，술후1개월강저위（234±22.3）μg/L；병인술전병조평균직경（50.2±11.3）mm，술후1개월병조평균직경위（38.2±6.9）mm（P<0.05）；술후3개월병조완전소실10례계12개병조，무명현변화자8개병조，여자균유불동정도축소。술후1개월초성조영현시97개（86.6%）병조정무혈류관주、변계청석적무증강상태，15개병조부분변연증강。결론초성인도하랭순배미파도연합사용초성조영창치료간암시일충십분유효적방법，작위미창치료간암수단치득추엄。
Objective To investigate the short-term outcome of ultrasound-guided psychro-circulation percutaneous microwave coagulation therapy in treatment for liver cancer. Methods From March 2008 to April 2010, 81 liver cancer patients with 112 lesions underwent psychro-circulation percutaneous microwave coagulation therapy (PPMCT) in our hospital. Before operation, the contrast-enhanced ultrasound (CEUS) and the micro flow imaging (MFI) as well as the measurement of tumor size were taken. After operation, the inacti-vation of tumor and the changes in tumor size as well as serum AFP were measured. The survival rates of the patients after 1year, 2 years and 3 years were followed up and recorded. Results After one month treatment, serum AFP was significantly decreased from (429 ± 29.8) μg/L to (234 ± 22.3) μg/L(P<0.01) ; the average lesion diameter was also significantly reduced from (50.2 ± 11.3) mm to (38.2 ± 6.9) mm (P<0.05). Three months later, 12 lesions in 10 cases was completely disappeared; no significant changes were found in 8 le-sions, and the remaining lesions were reduced in various degree. After one month, CEUS showed 97 lesions (86.6%) had clear boundary without enhanced status, portion edge enhancement was found in 15 lesions. Conclusion Ultrasound-guided psychro-circulation percutaneous microwave coagulation therapy associated with CEUS treating liver cancer is a very effective minimally invasive method.