CAJ | 학술논문

研究苯并噻唑类化合物 TJ-1(2-间苯胺基苯并噻唑)、TJ-2(2-间苯胺基苯并噻唑-3，4，5-三甲氧基苯甲酰胺)、TJ-3(2-间苯胺基苯并噻唑-1H-吡唑-3-甲酰胺)对高脂模型小鼠抗氧化能力的影响．50只8周龄健康雄性C57BL/6,J小鼠适应性饲养1周后，根据体质量随机分为高脂组、白藜芦醇对照组、TJ-1组、TJ-2组和TJ-3组．高脂组喂饲相应高脂饲料，白藜芦醇对照组和各干预组小鼠喂饲高脂饲料并分别添加0.1%的白藜芦醇、TJ-1、TJ-2、TJ-3进行干预，干预12周后测定小鼠血清、肝脏和脑的超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)、过氧化氢酶(CAT)和丙二醛(MDA)的水平．与高脂组相比，TJ-1、TJ-2、TJ-3、白藜芦醇各组小鼠血清、肝脏和脑的 SOD、GSH-Px、CAT水平均高于高脂模型组，MDA水平低于高脂组．结果表明：苯并噻唑类化合物能改善高脂模型小鼠的抗氧化能力.
연구분병새서류화합물 TJ-1(2-간분알기분병새서)、TJ-2(2-간분알기분병새서-3，4，5-삼갑양기분갑선알)、TJ-3(2-간분알기분병새서-1H-필서-3-갑선알)대고지모형소서항양화능력적영향．50지8주령건강웅성C57BL/6,J소서괄응성사양1주후，근거체질량수궤분위고지조、백려호순대조조、TJ-1조、TJ-2조화TJ-3조．고지조위사상응고지사료，백려호순대조조화각간예조소서위사고지사료병분별첨가0.1%적백려호순、TJ-1、TJ-2、TJ-3진행간예，간예12주후측정소서혈청、간장화뇌적초양화물기화매(SOD)、곡광감태과양화물매(GSH-Px)、과양화경매(CAT)화병이철(MDA)적수평．여고지조상비，TJ-1、TJ-2、TJ-3、백려호순각조소서혈청、간장화뇌적 SOD、GSH-Px、CAT수평균고우고지모형조，MDA수평저우고지조．결과표명：분병새서류화합물능개선고지모형소서적항양화능력.
The effect of benzothiazole derivatives TJ-1(3-(benzo[d]thiazol-2-yl)benzenamine),TJ-2(N-(3-(benzo[d] thiazol-2-yl)phenyl)-3,4,5-trimethoxybenzamide),and TJ-3(N-(3-(benzo[d]thiazol-2-yl)phenyl)-1,H-pyrazole-3-carboxamide) on the antioxidating activities of mice with high fat diet was studied. Fifty 8-week-old male C57BL/6,J mice were quaran-tined for 1 week. They were then randomly assigned to the following five groups according to body weight:high fat diet group,resveratrol control group,TJ-1,group,TJ-2 group and TJ-3 group. The levels of superoxide dismutase(SOD), glutathione peroxidase(GSH-Px),catalase(CAT)and malondialdehyde(MDA)were measured after the treatment which lasted for 12 weeks. Compared with the high fat diet group,the SOD,GSH-Px and CAT levels in the serum,liver and brain of the other 4 groups were higher,and the MDA levels were lower. Benzothiazole derivatives can improve the antioxidating activities of high fat mice.