激光杂志
激光雜誌
격광잡지
LASER JOURNAL
2013年
6期
78-79
,共2页
基底细胞癌%TLR7%AP-1
基底細胞癌%TLR7%AP-1
기저세포암%TLR7%AP-1
basal cell carcinoma%TLR7%AP-1
提目的：观察基底细胞癌中TLR7和AP-1蛋白的表达，探讨二者与基底细胞癌发生发展的关系。方法：收集基底细胞癌患者皮损30例及正常人皮肤组织26例，采用免疫组织化学法检测癌组织中TLR7和AP-1蛋白的表达水平；分析TLR7和AP-1在基底细胞癌中的表达水平以及二者之间的相互关系。结果：TLR7和AP-1在癌组织中表达均较正常皮肤组织高（P＜0．05），表达水平与性别、年龄均无差异（ P＞0．05）；TLR7和AP-1在基底细胞癌中的蛋白表达水平成明显正相关（r＝0．78，p＜0．01）。结论：TLR7和AP -1蛋白在基底细胞癌中高表达，且二者的表达水平呈明显正相关；TLR7和AP-1可能与基底细胞癌的发生发展有关。
提目的：觀察基底細胞癌中TLR7和AP-1蛋白的錶達，探討二者與基底細胞癌髮生髮展的關繫。方法：收集基底細胞癌患者皮損30例及正常人皮膚組織26例，採用免疫組織化學法檢測癌組織中TLR7和AP-1蛋白的錶達水平；分析TLR7和AP-1在基底細胞癌中的錶達水平以及二者之間的相互關繫。結果：TLR7和AP-1在癌組織中錶達均較正常皮膚組織高（P＜0．05），錶達水平與性彆、年齡均無差異（ P＞0．05）；TLR7和AP-1在基底細胞癌中的蛋白錶達水平成明顯正相關（r＝0．78，p＜0．01）。結論：TLR7和AP -1蛋白在基底細胞癌中高錶達，且二者的錶達水平呈明顯正相關；TLR7和AP-1可能與基底細胞癌的髮生髮展有關。
제목적：관찰기저세포암중TLR7화AP-1단백적표체，탐토이자여기저세포암발생발전적관계。방법：수집기저세포암환자피손30례급정상인피부조직26례，채용면역조직화학법검측암조직중TLR7화AP-1단백적표체수평；분석TLR7화AP-1재기저세포암중적표체수평이급이자지간적상호관계。결과：TLR7화AP-1재암조직중표체균교정상피부조직고（P＜0．05），표체수평여성별、년령균무차이（ P＞0．05）；TLR7화AP-1재기저세포암중적단백표체수평성명현정상관（r＝0．78，p＜0．01）。결론：TLR7화AP -1단백재기저세포암중고표체，차이자적표체수평정명현정상관；TLR7화AP-1가능여기저세포암적발생발전유관。
Objective :To investigate the expression of TLR7 and AP - 1 in basal cell carcinoma , and to explore their possibilities of occurrence and development .Method The expression of TLR7 and AP -1 were detected in 30 cases of basal cell carcinoma and 26 cases of normal tissue .Specimens were detected by immunohistochemistry .Result Immunohistochemistry showed that TLR 7 and AP-1 were both highly expressed in tumor tissue (P<0 .05)and the expression of TLR7 and AP-1 in tumor tissue were significant positive correlation (r=0 .78 ,p<0 .01) .But the both expression were not statistically difference with gende and age (P> 0 .05) .Conclusion TLR7 and AP -1 were highly expressed in basal cell carcinoma ,and their expression level was significant positive correlation .These results suggested the TLR7 and AP -1 gene may play important roles in basal cell carcinoma occurrence and development .
