CAJ | 학술논문

目的：观察竹节三七的有效成分竹节三七总皂苷（total saponins of Panax japonicus，TSPJ）的抗炎镇痛作用并探讨其抗炎机理。方法：采用小鼠角叉菜胶足肿胀实验观察竹节三七总皂苷的抗炎作用，采用小鼠热板法痛阈实验以及小鼠对醋酸刺激的扭体反应实验观察竹节三七总皂苷的镇痛作用。结果：竹节三七总皂苷（50，100mg·kg^-1）能显著抑制角叉菜胶所致的小鼠足肿胀；竹节三七总皂苷（50，100mg·kg^-1）能升高小鼠热板法痛阈值，能减少醋酸刺激的扭体反应次数，竹节三七总皂苷100mg·kg^-1组尤为明显。结论：竹节三七总皂苷具有明显的抗炎镇痛作用，与对照组比较差异非常显著。
목적：관찰죽절삼칠적유효성분죽절삼칠총조감（total saponins of Panax japonicus，TSPJ）적항염진통작용병탐토기항염궤리。방법：채용소서각차채효족종창실험관찰죽절삼칠총조감적항염작용，채용소서열판법통역실험이급소서대작산자격적뉴체반응실험관찰죽절삼칠총조감적진통작용。결과：죽절삼칠총조감（50，100mg·kg^-1）능현저억제각차채효소치적소서족종창；죽절삼칠총조감（50，100mg·kg^-1）능승고소서열판법통역치，능감소작산자격적뉴체반응차수，죽절삼칠총조감100mg·kg^-1조우위명현。결론：죽절삼칠총조감구유명현적항염진통작용，여대조조비교차이비상현저。
Objective：Anti -inflammatory effect and analgesic action of TSPJ on several inflammatory models of animal. Methods： The anti - inflammatory effect of TSPJ was observed by carrageenin - induced paw edema test. Analgesic action of TSPJ was observed by hot plate test and the acetic acid - induced writhing test. Results： TSPJ （50,100mg.kg^-1 ）can inhibit carrageenin- induced paw edema. TSPJ（50,100mg. kg^-1 ）can rise hot plate of mice and reduce number of acetic acid - induced writhing on mice . Conclusion： TSPJ exerts a definite anti - in- flammatory effect on mice and has analgesic action.