中南民族大学学报：自然科学版
中南民族大學學報：自然科學版
중남민족대학학보：자연과학판
Journal of South-Central University for Nationalities
2012年
2期
57-60,F0003
,共5页
透明质酸结合蛋白%CD44s蛋白%乳腺浸润性微小乳头状癌%淋巴结转移
透明質痠結閤蛋白%CD44s蛋白%乳腺浸潤性微小乳頭狀癌%淋巴結轉移
투명질산결합단백%CD44s단백%유선침윤성미소유두상암%림파결전이
hyaluronic acid-binding protein%CD44s%lymph node metastasis%invasive micropapillary carcinoma of breast
目的：探讨透明质酸结合蛋白（HABP）和CD44s在乳腺浸润性微小乳头状癌（IMPC）的表达特征及与其高淋巴结转移的相互关系.方法：采用免疫组化染色方法检测21例IMPC及13例假性IMPC（Pseudo-IMPC）中HABP和CD44s的表达.结果：HABP在16例（76%）IMPC的癌细胞团与间质相接的外侧面以及间质细胞均高表达,而仅在3例（23%）Pseudo-IMPC中癌细胞膜或间质细胞弱表达,两组间差异明显（P=0.0042）.CD44s在15例（70%）IMPC中癌细胞连接面高表达,在8例（62%）Pseudo-IMPC中癌细胞膜全周表达阳性.此外,临床数据表明有18例IMPC及5例Pseudo-IMPC表现出淋巴结转移,且两组间差异显著（P=0.0078）.结论：HABP及CD44s的特殊表达作为两个重要的危险因子促进了IMPC的淋巴结转移.
目的：探討透明質痠結閤蛋白（HABP）和CD44s在乳腺浸潤性微小乳頭狀癌（IMPC）的錶達特徵及與其高淋巴結轉移的相互關繫.方法：採用免疫組化染色方法檢測21例IMPC及13例假性IMPC（Pseudo-IMPC）中HABP和CD44s的錶達.結果：HABP在16例（76%）IMPC的癌細胞糰與間質相接的外側麵以及間質細胞均高錶達,而僅在3例（23%）Pseudo-IMPC中癌細胞膜或間質細胞弱錶達,兩組間差異明顯（P=0.0042）.CD44s在15例（70%）IMPC中癌細胞連接麵高錶達,在8例（62%）Pseudo-IMPC中癌細胞膜全週錶達暘性.此外,臨床數據錶明有18例IMPC及5例Pseudo-IMPC錶現齣淋巴結轉移,且兩組間差異顯著（P=0.0078）.結論：HABP及CD44s的特殊錶達作為兩箇重要的危險因子促進瞭IMPC的淋巴結轉移.
목적：탐토투명질산결합단백（HABP）화CD44s재유선침윤성미소유두상암（IMPC）적표체특정급여기고림파결전이적상호관계.방법：채용면역조화염색방법검측21례IMPC급13례가성IMPC（Pseudo-IMPC）중HABP화CD44s적표체.결과：HABP재16례（76%）IMPC적암세포단여간질상접적외측면이급간질세포균고표체,이부재3례（23%）Pseudo-IMPC중암세포막혹간질세포약표체,량조간차이명현（P=0.0042）.CD44s재15례（70%）IMPC중암세포련접면고표체,재8례（62%）Pseudo-IMPC중암세포막전주표체양성.차외,림상수거표명유18례IMPC급5례Pseudo-IMPC표현출림파결전이,차량조간차이현저（P=0.0078）.결론：HABP급CD44s적특수표체작위량개중요적위험인자촉진료IMPC적림파결전이.
To investigate the expressions of hyaluronic acid-binding protein （HABP） and CD44s in invasive micropapillary carcinoma （IMPC） of breast cancer and to demonstrate causality between its expressions and high rate of lymph-node metastasis in IMPC of breast cancer. The expressions of HABP and CD44s in 21 IMPC cases and 13 Pseudo invasive mieropapillary carcinoma （Pseudo-IMPC） cases of breast cancer tissues were detected in 34 patients by the immunohistochemical SP method. The relationship between both the expressions of HABP and CD44s and the lymph-node metastasis of IMPC was compared by Fisher＇s exact test. HABP was strongly expressed in cell membrane and intercellular substance of cancer cells in 16 of 21 IMPC cases, but weakly expressed in cell membrane and intercellular substance of 3 of 13 Pseudo-IMPC cases. There was a significant difference in the HABP expression between IMPC and Pseudo-IMPC cases （P = 0. 0042）. CD44s was mainly localized to intercellular membrane of cancer cells in 15 of 21 IMPC cases, but strongly expressed in cell membrane of cancer cells in 8 of 13 Pseudo-IMPC cases. There was no significant difference in CD44s expression IMPC and Pseudo-IMPC cases. Moreover, 18 of 21 IMPC patients and 5 of 13 Pseudo-IMPC patients showed lymph node metastasis. There was a significant difference in the lymph node metastasis between IMPC and Pseudo-IMPC cases （P = 0. 0078 ）. These results indicate that the distinctive expressions of HABP and CD44s in IMPC are closely related to lymph node metastasis as important risk factors, and may provide important evidence regarding the diagnosis and treatment of IMPC.
