CAJ | 학술논문

为了解不同民族大学生乙型肝炎病毒（hepatitis B virus,HBV）基因型和亚型分布状况,采用限制性片段长度多态性聚合酶链反应（PCR-RFLP）技术,对中南民族大学93例来自15个民族乙肝大三阳学生血清HBV进行基因分型.结果表明：患者中HBV基因B型占61.3%（57/93）,C型占25.8%（24/93）,D型占4.3%（4/93）.说明各民族HBV基因型分布中,B型占绝对优势,C型次之,D型最少（P〈0.01）.且不同民族不影响HBV基因型的分布（P〉0.05）,C型和D型分布基本符合我国HBV基因型地理区域分布规律.
위료해불동민족대학생을형간염병독（hepatitis B virus,HBV）기인형화아형분포상황,채용한제성편단장도다태성취합매련반응（PCR-RFLP）기술,대중남민족대학93례래자15개민족을간대삼양학생혈청HBV진행기인분형.결과표명：환자중HBV기인B형점61.3%（57/93）,C형점25.8%（24/93）,D형점4.3%（4/93）.설명각민족HBV기인형분포중,B형점절대우세,C형차지,D형최소（P〈0.01）.차불동민족불영향HBV기인형적분포（P〉0.05）,C형화D형분포기본부합아국HBV기인형지리구역분포규률.
To investigate the distribution of Hepatitis B virus genotype and subgenotype among undergraduates from various nationalities, 93 HBV-DNA positive serum samples from 15 nationalities in South-Central University for Nationalities were analyzed by PCR-RFLP. The results indicated that HBV genotype B accounted for 61.3% （57/93）, genotype C accounted for 25.8% （24/93） and genotype D accounted for 4.3% （4/93）. This demonstrated that genotype B is dominant in all the nationalities, genotype C ranks secondly and least genotype D （ P 〈 0. O1 ）. Ethnic differences have no effect on the classification of HBV genotype （ P 〉 0. 05 ）. Moreover, distribution of genotype C and D basically coincides with the geographic distribution of HBV in China.